PMID- 20507373
OWN - NLM
STAT- MEDLINE
DCOM- 20100928
LR  - 20231103
IS  - 1600-051X (Electronic)
IS  - 0303-6979 (Print)
IS  - 0303-6979 (Linking)
VI  - 37
IP  - 6
DP  - 2010 Jun
TI  - Periodontal disease progression and glycaemic control among Gullah African 
      Americans with type-2 diabetes.
PG  - 501-9
LID - 10.1111/j.1600-051X.2010.01564.x [doi]
AB  - AIM: To evaluate associations between glycaemic control and periodontitis 
      progression among Gullah African Americans with type-2 diabetes mellitus (T2DM). 
      MATERIALS AND METHODS: From an ongoing clinical trial among T2DM Gullah, we 
      extracted a cohort previously in a cross-sectional study (N=88). Time from 
      baseline (previous study) to follow-up (trial enrollment, before treatment 
      interventions) ranged 1.93-4.08 years [mean=2.99, standard deviation (SD)=0.36]. 
      We evaluated tooth site-level periodontitis progression [clinical attachment loss 
      (CAL) worsening of > or =2 mm, periodontal probing depth (PPD) increases of > or 
      =2 mm and bleeding on probing (BOP) from none to present] by glycaemic control 
      status (well-controlled=HbA(1c)<7%, poorly-controlled=HbA(1c)> or =7%) using 
      multivariable generalized estimating equations logistic regression, nesting tooth 
      sites/person. RESULTS: Poorly-controlled T2DM (68.18%) was more prevalent than 
      well-controlled T2DM (31.82%). Proportions of tooth sites/person with CAL 
      progression between baseline and follow-up ranged 0.00-0.59 (mean=0.12, SD=0.12), 
      while PPD and BOP progression ranged 0.00-0.44 (mean=0.09, SD=0.11) and 0.00-0.96 
      (mean=0.24, SD=0.18), respectively. Site-level PPD at baseline was a significant 
      effect modifier of associations between poorly-controlled T2DM and site-level CAL 
      and PPD progression [adjusted odds ratios (OR) according to poorly-controlled 
      T2DM among PPD at baseline=3, 5 and 7 mm, respectively: CAL progression=1.93, 
      2.64, and 3.62, PPD progression=1.98, 2.76, and 3.84; p<0.05 for all]. Odds of 
      site-level BOP progression were increased (OR=1.24) for poorly-controlled T2DM, 
      yet the results were not significant (p=0.32). CONCLUSIONS: These findings from a 
      distinct, homogenous population further support the clinical relevance of 
      identifying patients with poor glycaemic control and periodontitis, particularly 
      among those with disparities for both diseases.
FAU - Bandyopadhyay, Dipankar
AU  - Bandyopadhyay D
AD  - Division of Biostatistics and Epidemiology, Medical University of South 
      Carolina,Charleston, SC, USA.
FAU - Marlow, Nicole M
AU  - Marlow NM
FAU - Fernandes, Jyotika K
AU  - Fernandes JK
FAU - Leite, Renata S
AU  - Leite RS
LA  - eng
GR  - P20 RR017696-02/RR/NCRR NIH HHS/United States
GR  - P20 RR017696-06/RR/NCRR NIH HHS/United States
GR  - M01 RR001070-327664/RR/NCRR NIH HHS/United States
GR  - M01 RR001070/RR/NCRR NIH HHS/United States
GR  - P20 RR017696/RR/NCRR NIH HHS/United States
PT  - Clinical Trial
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PL  - United States
TA  - J Clin Periodontol
JT  - Journal of clinical periodontology
JID - 0425123
RN  - 0 (Blood Glucose)
RN  - 0 (Glycated Hemoglobin A)
RN  - 0 (Hypoglycemic Agents)
SB  - IM
MH  - Adult
MH  - *Black or African American
MH  - Aged
MH  - Blood Glucose/*analysis
MH  - Body Mass Index
MH  - Cohort Studies
MH  - Cross-Sectional Studies
MH  - Diabetes Mellitus, Type 2/blood/ethnology/*prevention & control
MH  - Disease Progression
MH  - *Ethnicity
MH  - Female
MH  - Follow-Up Studies
MH  - Gingival Hemorrhage/ethnology/physiopathology
MH  - Glycated Hemoglobin/analysis
MH  - Humans
MH  - Hypoglycemic Agents/therapeutic use
MH  - Longitudinal Studies
MH  - Male
MH  - Middle Aged
MH  - Periodontal Attachment Loss/ethnology/physiopathology
MH  - Periodontal Pocket/ethnology/physiopathology
MH  - Periodontitis/ethnology/*physiopathology
MH  - Smoking
MH  - South Carolina
PMC - PMC2891073
MID - NIHMS208186
EDAT- 2010/05/29 06:00
MHDA- 2010/09/30 06:00
PMCR- 2010/06/23
CRDT- 2010/05/29 06:00
PHST- 2010/05/29 06:00 [entrez]
PHST- 2010/05/29 06:00 [pubmed]
PHST- 2010/09/30 06:00 [medline]
PHST- 2010/06/23 00:00 [pmc-release]
AID - CPE1564 [pii]
AID - 10.1111/j.1600-051X.2010.01564.x [doi]
PST - ppublish
SO  - J Clin Periodontol. 2010 Jun;37(6):501-9. doi: 10.1111/j.1600-051X.2010.01564.x.