PMID- 20507388
OWN - NLM
STAT- MEDLINE
DCOM- 20100831
LR  - 20111117
IS  - 1346-8138 (Electronic)
IS  - 0385-2407 (Linking)
VI  - 37
IP  - 3
DP  - 2010 Mar
TI  - Association of human leukocyte antigen class II alleles with pemphigus vulgaris 
      in a Turkish population.
PG  - 246-50
LID - 10.1111/j.1346-8138.2009.00743.x [doi]
AB  - Pemphigus vulgaris (PV) is a severe autoimmune blistering skin disorder that is 
      strongly associated with major histocompatibility complex class II alleles. Human 
      leukocyte antigen (HLA) subtypes vary with racial/ethnic backgrounds. The purpose 
      of this study was to determine the association of HLA class II alleles and 
      haplotypes with PV in Turkish patients. Twenty-five patients with PV and 113 
      healthy transplant donors were genotyped for HLA class II alleles. HLA DNA typing 
      was performed by the polymerase chain reaction/sequence specific primer method. 
      The frequency of HLA DRB1*04 allele was 68.00% in patients compared to 30.97% in 
      controls (P = 0.0012) and the frequency of HLA DRB1*14 allele was 32.00% in the 
      patient group compared to 8.85% in the control group (P = 0.0054). Also, the 
      frequency of HLA DRB1*04/DQB1*03 and HLA DRB1*14/DQB1*05 haplotypes in PV 
      patients was significantly higher than controls (32.0% vs 6.2%, chi(2) = 28.142, 
      P < 0.001; and 16% vs 2.7%, chi(2) = 15.143, P = 0.001, respectively). A 
      preventive allele or haplotype for the manifestation of PV has not been 
      identified in this study. Our findings suggest that HLA DRB1*04 and DRB1*14 
      alleles, and HLA DRB1*04/DQB1*03 and HLA DRB1*14/DQB1*05 haplotypes are genetic 
      markers for general susceptibility to PV in the Turkish population.
FAU - Tunca, Mustafa
AU  - Tunca M
AD  - Department of Dermatology, Gulhane School of Medicine, GATA, Ankara, Turkey. 
      msttnc@hotmail.com
FAU - Musabak, Ugur
AU  - Musabak U
FAU - Sagkan, Rahsan Ilikci
AU  - Sagkan RI
FAU - Koc, Erol
AU  - Koc E
FAU - Akar, Ahmet
AU  - Akar A
LA  - eng
PT  - Journal Article
PL  - England
TA  - J Dermatol
JT  - The Journal of dermatology
JID - 7600545
RN  - 0 (HLA-DR Antigens)
RN  - 0 (HLA-DRB1 Chains)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Alleles
MH  - Female
MH  - Gene Frequency
MH  - Genetic Association Studies
MH  - *Genetic Predisposition to Disease
MH  - HLA-DR Antigens/*genetics
MH  - HLA-DRB1 Chains
MH  - Haplotypes
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Pemphigus/*genetics
MH  - Turkey
MH  - Young Adult
EDAT- 2010/05/29 06:00
MHDA- 2010/09/02 06:00
CRDT- 2010/05/29 06:00
PHST- 2010/05/29 06:00 [entrez]
PHST- 2010/05/29 06:00 [pubmed]
PHST- 2010/09/02 06:00 [medline]
AID - JDE743 [pii]
AID - 10.1111/j.1346-8138.2009.00743.x [doi]
PST - ppublish
SO  - J Dermatol. 2010 Mar;37(3):246-50. doi: 10.1111/j.1346-8138.2009.00743.x.