PMID- 20508038
OWN - NLM
STAT- MEDLINE
DCOM- 20101112
LR  - 20211020
IS  - 1468-2079 (Electronic)
IS  - 0007-1161 (Print)
IS  - 0007-1161 (Linking)
VI  - 94
IP  - 11
DP  - 2010 Nov
TI  - Rate and risk factors for cataract formation and extraction after Descemet 
      stripping endothelial keratoplasty.
PG  - 1468-71
LID - 10.1136/bjo.2009.175174 [doi]
AB  - PURPOSE: To assess the rate and risk factors for cataract formation and 
      extraction after Descemet stripping endothelial keratoplasty (DSEK). METHODS: An 
      initial, consecutive series of 1050 primary DSEK procedures was reviewed to 
      identify eyes that remained phakic. Only the first-treated eye of each patient 
      was included; 60 eyes qualified. Rate and risk factors for subsequent cataract 
      formation and extraction were assessed by multivariate proportional hazards 
      modelling and survival analysis. RESULTS: Median patient age was 52 years (range: 
      32-69 years), and median graft diameter was 8.5 mm (range: 8-9 mm). Median 
      follow-up was 32 months (range: 1-51 months). Cataract extraction was performed 
      after DSEK in 22 eyes (37%) without complication and all grafts remained clear 
      with median follow-up of 18 months (range: 1-44 months). Six eyes were regrafted; 
      all underwent cataract extraction either simultaneously (n = 4) or subsequently 
      (n = 2). At 1 and 3 years, respectively, the probability of cataract extraction 
      was 0% and 7% in patients who were 50 years or younger at the time of DSEK (n = 
      20) versus 31% and 55% in older patients (n = 40), a statistically significant 
      difference (p = 0.0005). CONCLUSIONS: Rates of cataract formation and extraction 
      after DSEK were significantly higher in patients over 50 years of age and 
      substantially exceeded normal population rates.
FAU - Price, Marianne O
AU  - Price MO
AD  - Cornea Research Foundation of America, Indianapolis, IN 46260, USA. 
      marianneprice@cornea.org
FAU - Price, David A
AU  - Price DA
FAU - Fairchild, Kelly M
AU  - Fairchild KM
FAU - Price, Francis W Jr
AU  - Price FW Jr
LA  - eng
PT  - Journal Article
DEP - 20100527
PL  - England
TA  - Br J Ophthalmol
JT  - The British journal of ophthalmology
JID - 0421041
RN  - 0 (Steroids)
SB  - IM
MH  - Adult
MH  - Age Factors
MH  - Aged
MH  - Cataract/*etiology/pathology
MH  - Cataract Extraction/statistics & numerical data
MH  - Cell Count
MH  - Descemet Stripping Endothelial Keratoplasty/*adverse effects
MH  - Endothelial Cells/pathology
MH  - Female
MH  - Fuchs' Endothelial Dystrophy/pathology/*surgery
MH  - Graft Rejection/prevention & control
MH  - Humans
MH  - Kaplan-Meier Estimate
MH  - Male
MH  - Middle Aged
MH  - Reoperation
MH  - Retrospective Studies
MH  - Risk Factors
MH  - Steroids/therapeutic use
MH  - Treatment Outcome
PMC - PMC2976606
COIS- Competing interests: None.
EDAT- 2010/05/29 06:00
MHDA- 2010/11/13 06:00
PMCR- 2010/05/27
CRDT- 2010/05/29 06:00
PHST- 2010/05/29 06:00 [entrez]
PHST- 2010/05/29 06:00 [pubmed]
PHST- 2010/11/13 06:00 [medline]
PHST- 2010/05/27 00:00 [pmc-release]
AID - bjo.2009.175174 [pii]
AID - bjophthalmol175174 [pii]
AID - 10.1136/bjo.2009.175174 [doi]
PST - ppublish
SO  - Br J Ophthalmol. 2010 Nov;94(11):1468-71. doi: 10.1136/bjo.2009.175174. Epub 2010 
      May 27.