PMID- 20509034
OWN - NLM
STAT- MEDLINE
DCOM- 20101202
LR  - 20100727
IS  - 1432-5233 (Electronic)
IS  - 0940-5429 (Linking)
VI  - 47
IP  - 3
DP  - 2010 Sep
TI  - Serum levels of proamylin and amylin in normal subjects and patients with 
      impaired glucose regulation and type 2 diabetes mellitus.
PG  - 265-70
LID - 10.1007/s00592-010-0201-9 [doi]
AB  - Amylin is the major constituent of pancreatic islet amyloid whose accumulation 
      characterizes patients with type 2 diabetes mellitus (T2DM). Although amylin is 
      tightly linked with T2DM, in many cases, proamylin may be the more toxic species. 
      As the precursor of amylin, however, the pathophysiological role of proamylin 
      remains unknown. In this study, we investigate whether serum levels of proamylin 
      or amylin or the proamylin/amylin ratios are different among normal subjects and 
      patients with impaired glucose regulation (IGR) and T2DM. Totally 79 subjects 
      were divided into three groups according to the results of oral glucose tolerance 
      test (OGTT); they were T2DM group (32 cases), IGR group (23cases), and normal 
      glucose tolerance (NGT) group (24cases). Serum levels of amylin and proamylin 
      were measured with an enzyme-linked immunosorbent assay (ELISA). The 
      relationships between serum levels of proamylin, amylin, their ratios and 
      anthropometric and metabolic parameters were also analyzed. The serum levels of 
      proamylin were significantly higher in patients with IGR and T2DM than in control 
      subjects. The serum levels of proamylin were significantly associated with IGR 
      and T2DM, with the odds ratios of 1.589 (95%CI, 1.228-2.055, P < 0.01) and 1.860 
      (95%CI, 1.342-2.587, P < 0.01), respectively. Both fasting serum levels of 
      proamylin and proamylin/amylin ratios were found to correlate negatively with 
      HOMA-B and DeltaI30/DeltaG30. Serum levels of proamylin, amylin, and their ratios 
      were positively correlated with HOMA-IR. BMI and HOMA-B were independent related 
      factors with serum levels of proamylin. Our results suggest that proamylin may 
      play an important role in amyloid deposit in patients with IGR and T2DM.
FAU - Zheng, Xiaoya
AU  - Zheng X
AD  - Department of Endocrinology, The First Affiliated Hospital, Chongqing Medical 
      University, China.
FAU - Ren, Wei
AU  - Ren W
FAU - Zhang, Suhua
AU  - Zhang S
FAU - Liu, Jingjing
AU  - Liu J
FAU - Li, Sufang
AU  - Li S
FAU - Li, Jinchao
AU  - Li J
FAU - Yang, Ping
AU  - Yang P
FAU - He, Jun
AU  - He J
FAU - Su, Shaochu
AU  - Su S
FAU - Li, Ping
AU  - Li P
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100528
PL  - Germany
TA  - Acta Diabetol
JT  - Acta diabetologica
JID - 9200299
RN  - 0 (Blood Glucose)
RN  - 0 (Islet Amyloid Polypeptide)
RN  - 0 (Lipids)
RN  - 0 (Protein Precursors)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Blood Glucose/analysis/metabolism
MH  - Body Composition/physiology
MH  - Diabetes Mellitus, Type 2/*blood/diagnosis/metabolism/physiopathology
MH  - Female
MH  - Glucose Intolerance/*blood/complications/metabolism/physiopathology
MH  - Glucose Tolerance Test
MH  - Humans
MH  - *Insulin Resistance/physiology
MH  - Islet Amyloid Polypeptide/analysis/*blood
MH  - Lipids/blood
MH  - Male
MH  - Middle Aged
MH  - Protein Precursors/analysis/*blood
MH  - Serum/chemistry/metabolism
EDAT- 2010/05/29 06:00
MHDA- 2010/12/14 06:00
CRDT- 2010/05/29 06:00
PHST- 2010/01/12 00:00 [received]
PHST- 2010/05/19 00:00 [accepted]
PHST- 2010/05/29 06:00 [entrez]
PHST- 2010/05/29 06:00 [pubmed]
PHST- 2010/12/14 06:00 [medline]
AID - 10.1007/s00592-010-0201-9 [doi]
PST - ppublish
SO  - Acta Diabetol. 2010 Sep;47(3):265-70. doi: 10.1007/s00592-010-0201-9. Epub 2010 
      May 28.