PMID- 20510319
OWN - NLM
STAT- MEDLINE
DCOM- 20101115
LR  - 20221207
IS  - 1879-1166 (Electronic)
IS  - 0198-8859 (Linking)
VI  - 71
IP  - 8
DP  - 2010 Aug
TI  - Effect of human leukocyte antigen class II genes on acute-onset and slow-onset 
      type 1 diabetes in the Japanese population.
PG  - 789-94
LID - 10.1016/j.humimm.2010.05.020 [doi]
AB  - The contribution of the human leukocyte antigen (HLA) subtype to slow-onset type 
      1 diabetes (T1D), which includes latent autoimmune diabetes in adults (LADA), 
      remains unclear in the Japanese population. We compared the frequencies of HLA 
      DR-DQ haplotypes and genotypes of 72 acute-onset T1D patients, 100 slow-onset T1D 
      patients, and 292 control subjects. The frequencies of DRB1*0405-DQB1*0401 (DR4) 
      and DRB1*1302-DQB1*0604 (DR13) haplotypes were significantly higher in 
      acute-onset patients, whereas that of the DRB1*1502-DQB1*0601 haplotype was 
      significantly lower than those in slow-onset diabetes patients and controls. In 
      contrast, DRB1*0802-DQB1*0302 (DR8) and DRB1*0901-DQB1*0303 (DR9) haplotypes were 
      significantly more frequent, and the DRB1*1501-DQB1*0602 haplotype was extremely 
      rare, in acute-onset patients and slow-onset diabetes patients. Genotype analysis 
      revealed that DR4/9, DR4/13, and DR9/13 in acute-onset patients indicated high 
      odds ratios (6.81, 12.0, and 15.6, respectively), whereas DR4/8 was significantly 
      more frequent in slow-onset diabetes patients, but not in acute-onset patients. 
      Our study demonstrated for the first time that the DR8 haplotype confers 
      susceptibility to slow-onset T1D in the Japanese population. Moreover, there 
      potentially are hierarchies for predisposing haplotypes, namely, DR13 > DR4 > DR9 
      > DR8 and for protective haplotypes, namely, DRB1*1501-DQB1*0602 > 
      DRB1*1502-DQB1*0601.
CI  - Copyright 2010 American Society for Histocompatibility and Immunogenetics. 
      Published by Elsevier Inc. All rights reserved.
FAU - Katahira, Masahito
AU  - Katahira M
AD  - Department of Endocrinology and Diabetes, Ichinomiya Municipal Hospital, 
      Ichinomiya, Japan. katahira-0034@umin.net
FAU - Segawa, Satoko
AU  - Segawa S
FAU - Maeda, Harumi
AU  - Maeda H
FAU - Yasuda, Yoshinori
AU  - Yasuda Y
LA  - eng
PT  - Journal Article
DEP - 20100525
PL  - United States
TA  - Hum Immunol
JT  - Human immunology
JID - 8010936
RN  - 0 (HLA-DQ Antigens)
RN  - 0 (HLA-DQ beta-Chains)
RN  - 0 (HLA-DQB1 antigen)
RN  - 0 (HLA-DR Antigens)
RN  - 0 (HLA-DRB1 Chains)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Alleles
MH  - Asian People/genetics
MH  - Child
MH  - Child, Preschool
MH  - Diabetes Mellitus, Type 1/ethnology/*genetics
MH  - Gene Frequency
MH  - Genetic Predisposition to Disease/*genetics
MH  - Genotype
MH  - HLA-DQ Antigens/*genetics
MH  - HLA-DQ beta-Chains
MH  - HLA-DR Antigens/*genetics
MH  - HLA-DRB1 Chains
MH  - *Haplotypes
MH  - Humans
MH  - Japan
MH  - Linkage Disequilibrium
MH  - Middle Aged
MH  - Sequence Analysis, DNA
MH  - Young Adult
EDAT- 2010/06/01 06:00
MHDA- 2010/11/16 06:00
CRDT- 2010/06/01 06:00
PHST- 2009/12/16 00:00 [received]
PHST- 2010/05/13 00:00 [revised]
PHST- 2010/05/19 00:00 [accepted]
PHST- 2010/06/01 06:00 [entrez]
PHST- 2010/06/01 06:00 [pubmed]
PHST- 2010/11/16 06:00 [medline]
AID - S0198-8859(10)00131-X [pii]
AID - 10.1016/j.humimm.2010.05.020 [doi]
PST - ppublish
SO  - Hum Immunol. 2010 Aug;71(8):789-94. doi: 10.1016/j.humimm.2010.05.020. Epub 2010 
      May 25.