PMID- 20511533 OWN - NLM STAT- MEDLINE DCOM- 20100915 LR - 20180404 IS - 1554-6063 (Electronic) IS - 0145-7217 (Linking) VI - 36 Suppl 2 DP - 2010 May-Jun TI - A new look at established therapies: practical tools for optimizing insulin use. PG - 26S-38S; quiz 39S-40S LID - 10.1177/0145721710369637 [doi] AB - PURPOSE: Current evidence shows early initiation of insulin therapy in type 2 diabetes mellitus (T2DM) improves glycemic control, responsiveness to subsequent oral antidiabetic therapies, beta-cell function, and possible cardiovascular outcomes. The American Diabetes Association (ADA)/European Association for the Study of Diabetes (EASD) 2008 algorithm introduces insulin therapy earlier in the treatment of T2DM with prompt intensification to achieve therapeutic goals. Agent selection and insulin regimens are based on patient A1C levels and willingness to monitor blood glucose, use of previous medications, blood glucose patterns, diet, and lifestyle. Practical considerations offered for diabetes educators and clinicians include creating strategies for early initiation of insulin, addressing patients' psychosocial barriers and quality of life concerns, understanding pharmacokinetic properties of insulin formulations, selecting appropriate therapy and patient-based regimens, and intensifying therapy to achieve glycemic control. CONCLUSIONS: Diabetes education, including intentional curriculum design, for patients with T2DM who are initiating or intensifying insulin therapy, addresses patient barriers to care, reduces the burden of treatment, improves adherence to treatment protocols, and helps optimize clinical outcomes. FAU - Gavin, James R 3rd AU - Gavin JR 3rd AD - Healing Our Village, Inc, and Emory University School of Medicine, Atlanta, GA (Dr Gavin) FAU - Peragallo-Dittko, Virginia AU - Peragallo-Dittko V AD - The Diabetes Education Center, Winthrop-University Hospital, Mineola, NY (Ms Peragallo-Dittko) FAU - Rodgers, Philip T AU - Rodgers PT AD - The University of North Carolina Eshelman School of Pharmacy, Duke University Hospital, and Duke Area Health Education Centers, Durham, NC (Mr Rodgers) LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't PL - United States TA - Diabetes Educ JT - The Diabetes educator JID - 7701401 RN - 0 (Hypoglycemic Agents) RN - 0 (Insulin) RN - 0 (Sulfonylurea Compounds) RN - 9100L32L2N (Metformin) MH - Algorithms MH - Diabetes Mellitus/*drug therapy/rehabilitation MH - Humans MH - Hypoglycemic Agents/*therapeutic use MH - Insulin/*therapeutic use MH - Metformin/therapeutic use MH - Patient Education as Topic MH - Reproducibility of Results MH - Sulfonylurea Compounds/therapeutic use EDAT- 2010/06/04 06:00 MHDA- 2010/09/16 06:00 CRDT- 2010/06/01 06:00 PHST- 2010/06/01 06:00 [entrez] PHST- 2010/06/04 06:00 [pubmed] PHST- 2010/09/16 06:00 [medline] AID - 36/2_suppl/26S [pii] AID - 10.1177/0145721710369637 [doi] PST - ppublish SO - Diabetes Educ. 2010 May-Jun;36 Suppl 2:26S-38S; quiz 39S-40S. doi: 10.1177/0145721710369637.