PMID- 20514306
OWN - NLM
STAT- MEDLINE
DCOM- 20100908
LR  - 20211020
IS  - 1598-6357 (Electronic)
IS  - 1011-8934 (Print)
IS  - 1011-8934 (Linking)
VI  - 25
IP  - 6
DP  - 2010 Jun
TI  - The relationship between the presence of chromosomal instability and prognosis of 
      squamous cell carcinoma of the lung: fluorescence in situ hybridization analysis 
      of paraffin-embedded tissue from 47 Korean patients.
PG  - 863-7
LID - 10.3346/jkms.2010.25.6.863 [doi]
AB  - To evaluate the prognostic importance of chromosomal instability (CIN) in 
      squamous cell carcinoma (SCC) of the lung, the relationship between CIN detected 
      by fluorescence in situ hybridization (FISH) and survival in SCC patients was 
      examined. Forty-seven surgical specimens of lung SCC were analyzed. To identify 
      tumors with CIN, p16 and multi-target DNA FISH assays for c-myc, chromosome 6, 
      EGFR, and chromosome 5 (LAVysion, Vysis) were performed on nuclei extracted from 
      paraffin-embedded tumor tissues. Survival rates were compared in terms of age, T 
      factor, N factor, CIN, and smoking status. A sample was defined as CIN-positive 
      if at least four of the five chromosomes were positive. Among the 47 specimens, 9 
      (19%) were CIN-positive. The overall survival rate was 66%. Overall survival 
      rates were estimated as 33.3% for CIN-positive patients and 76.7% for 
      CIN-negative patients (Hazard ratio 3.47; 95% Confidence interval, 1.25-9.67; 
      P=0.017). In multivariate analysis, the presence of CIN was a predictive factor 
      for survival. CIN-positive based on FISH can be prognostic factor of lung SCC.
FAU - Yoo, Jung-Wan
AU  - Yoo JW
AD  - Department of Pulmonary and Critical Care Medicine, Asan Medical Center, College 
      of Medicine, University of Ulsan, Seoul, Korea.
FAU - Seo, Kwang Won
AU  - Seo KW
FAU - Jang, Se Jin
AU  - Jang SJ
FAU - Oh, Yeon-Mock
AU  - Oh YM
FAU - Shim, Tae Sun
AU  - Shim TS
FAU - Kim, Woo Sung
AU  - Kim WS
FAU - Lee, Dong-Soon
AU  - Lee DS
FAU - Lee, Sang-Do
AU  - Lee SD
FAU - Choi, Chang-Min
AU  - Choi CM
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100524
PL  - Korea (South)
TA  - J Korean Med Sci
JT  - Journal of Korean medical science
JID - 8703518
RN  - 0 (Proto-Oncogene Proteins c-myb)
RN  - EC 2.7.10.1 (EGFR protein, human)
RN  - EC 2.7.10.1 (ErbB Receptors)
SB  - IM
MH  - Adult
MH  - Age Factors
MH  - Aged
MH  - Carcinoma, Squamous Cell/*mortality/pathology
MH  - *Chromosomal Instability
MH  - Chromosomes, Human, Pair 5
MH  - Chromosomes, Human, Pair 6
MH  - ErbB Receptors/metabolism
MH  - Female
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Lung Neoplasms/*mortality/pathology
MH  - Male
MH  - Middle Aged
MH  - Neoplasm Staging
MH  - Paraffin Embedding
MH  - Prognosis
MH  - Proto-Oncogene Proteins c-myb/metabolism
MH  - Republic of Korea
MH  - Smoking
MH  - Survival Rate
PMC - PMC2877246
OTO - NOTNLM
OT  - Carcinoma, Squamous Cell
OT  - Chromosomal Instability
OT  - In Situ Hybridization, Fluorescence
OT  - Lung Neoplasms
EDAT- 2010/06/02 06:00
MHDA- 2010/09/09 06:00
PMCR- 2010/06/01
CRDT- 2010/06/02 06:00
PHST- 2009/09/15 00:00 [received]
PHST- 2009/12/21 00:00 [accepted]
PHST- 2010/06/02 06:00 [entrez]
PHST- 2010/06/02 06:00 [pubmed]
PHST- 2010/09/09 06:00 [medline]
PHST- 2010/06/01 00:00 [pmc-release]
AID - 10.3346/jkms.2010.25.6.863 [doi]
PST - ppublish
SO  - J Korean Med Sci. 2010 Jun;25(6):863-7. doi: 10.3346/jkms.2010.25.6.863. Epub 
      2010 May 24.