PMID- 20514321
OWN - NLM
STAT- MEDLINE
DCOM- 20100908
LR  - 20211020
IS  - 1598-6357 (Electronic)
IS  - 1011-8934 (Print)
IS  - 1011-8934 (Linking)
VI  - 25
IP  - 6
DP  - 2010 Jun
TI  - A case of multiple endocrine neoplasia type 1 with primary liver gastrinoma.
PG  - 953-6
LID - 10.3346/jkms.2010.25.6.953 [doi]
AB  - Gastrinoma is the most frequent functional pancreaticoduodenal endocrine tumor in 
      patients with multiple endocrine neoplasia type 1 (MEN 1). Primary hepatic 
      gastrinomas in MEN 1 are very rare, with no previous reports published in the 
      literature. We reported the case of a 39 yr old female patient with a history of 
      repeated peptic ulcers and a hypoglycemia episode. Abdominal CT indicated a 
      well-defined liver mass and a pancreatic head mass. Somatostatin-receptor 
      scintigraphy with [(111)In] DTPA octreotide demonstrated a strong uptake of the 
      radiotracer in the left lateral segment at the site of the hepatic mass. After 
      operation, immunohistochemical staining was consistent with pancreatic insulinoma 
      and primary hepatic gastrinoma. As the liver is a common site of metastases from 
      gastrinoma, primary liver gastrinoma has not yet been reported with MEN 1. We 
      diagnosed this patient using immunohistochemical studies and treated this patient 
      by hepatic segmentectomy.
FAU - Lee, Sul Ra
AU  - Lee SR
AD  - Department of Endocrinology and Metabolism, Kyung Hee University School of 
      Medicine, Seoul, Korea.
FAU - Choi, Moon Chan
AU  - Choi MC
FAU - Ahn, Kyu Jeung
AU  - Ahn KJ
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20100525
PL  - Korea (South)
TA  - J Korean Med Sci
JT  - Journal of Korean medical science
JID - 8703518
SB  - IM
MH  - Adult
MH  - Female
MH  - Gastrinoma/complications/*diagnosis/pathology
MH  - Humans
MH  - Hypoglycemia/etiology
MH  - Insulinoma/complications/diagnosis/pathology
MH  - Liver Neoplasms/complications/*diagnosis/pathology
MH  - Mastectomy, Segmental
MH  - Multiple Endocrine Neoplasia Type 1/complications/*diagnosis
MH  - Pancreatic Neoplasms/complications/diagnosis/pathology
MH  - Peptic Ulcer/etiology
MH  - Tomography, X-Ray Computed
PMC - PMC2877224
OTO - NOTNLM
OT  - Gastrinoma
OT  - Insulinoma
OT  - Multiple Endocrine Neoplasia Type 1
EDAT- 2010/06/02 06:00
MHDA- 2010/09/09 06:00
PMCR- 2010/06/01
CRDT- 2010/06/02 06:00
PHST- 2008/12/22 00:00 [received]
PHST- 2009/03/17 00:00 [accepted]
PHST- 2010/06/02 06:00 [entrez]
PHST- 2010/06/02 06:00 [pubmed]
PHST- 2010/09/09 06:00 [medline]
PHST- 2010/06/01 00:00 [pmc-release]
AID - 10.3346/jkms.2010.25.6.953 [doi]
PST - ppublish
SO  - J Korean Med Sci. 2010 Jun;25(6):953-6. doi: 10.3346/jkms.2010.25.6.953. Epub 
      2010 May 25.