PMID- 20514596
OWN - NLM
STAT- MEDLINE
DCOM- 20100701
LR  - 20201209
IS  - 1439-4413 (Electronic)
IS  - 0012-0472 (Linking)
VI  - 135
IP  - 23
DP  - 2010 Jun
TI  - [HIV-therapy-associated immune reconstitution syndrome presenting as immunogenic 
      hyperthyroidism].
PG  - 1171-4
LID - 10.1055/s-0030-1255125 [doi]
AB  - HISTORY AND CLINICAL FINDINGS: A 51-year-old man infected with HIV-1 presented 
      with weight loss, weakness, fever, agitation, tachycardia and tremor first 
      occurring three year after initiation of antiretroviral therapy. INVESTIGATIONS: 
      The electrocardiogram showed atrial fibrillation. Laboratory findings revealed 
      hyperthyroidism with fully suppressed thyroid stimulating hormone (TSH). 
      Antibodies against thyroid globulin and TSH-receptor were markedly increased. 
      Both alpha-fodrin antibodies and antinuclear antibodies were abnormal. 
      Retrospective analysis revealed an association of hyperthyroidism and the 
      presence of autoantibodies with a sudden immune reconstitution under HIV-therapy. 
      DIAGNOSIS, TREATMENT AND COURSE: An immune reconstitution inflammatory syndrome 
      (IRIS) presenting as Graves's disease was diagnosed and treated with radioiodide. 
      The patient recovered to clinical euthyroidism while antiretroviral treatment 
      remained unchanged. CONCLUSION: IRIS against infectious or self-antigens during 
      HIV treatment results from local or systemic inflammatory imbalances. IRIS with 
      autoimmune manifestations may occur even years after initiation of an effective 
      antiretroviral therapy.
CI  - Georg Thieme Verlag KG Stuttgart, New York.
FAU - Ho, N A H
AU  - Ho NA
AD  - Klinik fur Immunologie und Rheumatologie, Medizinische Hochschule Hannover.
FAU - Schmidt, R E
AU  - Schmidt RE
FAU - Behrens, G
AU  - Behrens G
LA  - ger
PT  - Case Reports
PT  - Journal Article
TT  - Immunogene Hyperthyreose als Immunrekonstitutionssyndrom unter HIV-Therapie.
DEP - 20100531
PL  - Germany
TA  - Dtsch Med Wochenschr
JT  - Deutsche medizinische Wochenschrift (1946)
JID - 0006723
RN  - 0 (Alkynes)
RN  - 0 (Anti-HIV Agents)
RN  - 0 (Autoantibodies)
RN  - 0 (Benzoxazines)
RN  - 0 (Cyclopropanes)
RN  - 0 (Organophosphonates)
RN  - 0W860991D6 (Deoxycytidine)
RN  - 99YXE507IL (Tenofovir)
RN  - G70B4ETF4S (Emtricitabine)
RN  - JAC85A2161 (Adenine)
RN  - JE6H2O27P8 (efavirenz)
SB  - IM
MH  - Adenine/adverse effects/*analogs & derivatives/therapeutic use
MH  - Alkynes
MH  - Anti-HIV Agents/*adverse effects/therapeutic use
MH  - Autoantibodies/blood
MH  - Benzoxazines/*adverse effects/therapeutic use
MH  - Cyclopropanes
MH  - Deoxycytidine/adverse effects/*analogs & derivatives/therapeutic use
MH  - Diagnosis, Differential
MH  - Drug Therapy, Combination
MH  - Emtricitabine
MH  - Graves Disease/chemically induced/diagnosis/immunology
MH  - HIV Infections/*drug therapy/immunology
MH  - *HIV-1
MH  - Humans
MH  - Immune Reconstitution Inflammatory Syndrome/*chemically 
      induced/diagnosis/immunology
MH  - Long-Term Care
MH  - Male
MH  - Middle Aged
MH  - Organophosphonates/*adverse effects/therapeutic use
MH  - Tenofovir
MH  - Thyroid Gland/immunology
MH  - Thyroiditis, Autoimmune/*chemically induced/diagnosis/immunology
EDAT- 2010/06/02 06:00
MHDA- 2010/07/02 06:00
CRDT- 2010/06/02 06:00
PHST- 2010/06/02 06:00 [entrez]
PHST- 2010/06/02 06:00 [pubmed]
PHST- 2010/07/02 06:00 [medline]
AID - 10.1055/s-0030-1255125 [doi]
PST - ppublish
SO  - Dtsch Med Wochenschr. 2010 Jun;135(23):1171-4. doi: 10.1055/s-0030-1255125. Epub 
      2010 May 31.