PMID- 20515643
OWN - NLM
STAT- MEDLINE
DCOM- 20101110
LR  - 20240109
IS  - 1096-0384 (Electronic)
IS  - 0003-9861 (Linking)
VI  - 504
IP  - 1
DP  - 2010 Dec 1
TI  - Fucoxanthin regulates adipocytokine mRNA expression in white adipose tissue of 
      diabetic/obese KK-Ay mice.
PG  - 17-25
LID - 10.1016/j.abb.2010.05.031 [doi]
AB  - Fucoxanthin, a marine carotenoid found in edible brown seaweeds, attenuates white 
      adipose tissue (WAT) weight gain and hyperglycemia in diabetic/obese KK-A(y) 
      mice, although it does not affect these parameters in lean C57BL/6J mice. In 
      perigonadal and mesenteric WATs of KK-A(y) mice fed fucoxanthin, mRNA expression 
      levels of monocyte chemoattractant protein-1 (MCP-1) and tumor necrosis factor-alpha 
      (TNF-alpha), which are considered to induce insulin resistance, were markedly reduced 
      compared to control mice. In contrast to KK-A(y) mice, fucoxanthin did not alter 
      MCP-1 and TNF-alpha mRNA expression levels in the WAT of lean C57BL/6J mice. 
      Interleukin-6 (IL-6) and plasminogen activator inhibitor-1 mRNA expression levels 
      in WAT were also decreased by fucoxanthin in KK-A(y) mice. In differentiating 
      3T3-F442A adipocytes, fucoxanthinol, which is a fucoxanthin metabolite found in 
      WAT, attenuated TNF-alpha-induced MCP-1 and IL-6 mRNA overexpression and protein 
      secretion into the culture medium. In addition, fucoxanthinol decreased TNF-alpha, 
      inducible nitric oxide synthase (iNOS), and cyclooxygenase-2 (COX-2) mRNA 
      expression in RAW264.7 macrophage-like cells stimulated by palmitic acid. These 
      findings indicate that fucoxanthin regulates mRNA expression of inflammatory 
      adipocytokines involved in insulin resistance, iNOS, and COX-2 in WAT and has 
      specific effects on diabetic/obese KK-A(y) mice, but not on lean C57BL/6J mice.
CI  - Copyright (c) 2010 Elsevier Inc. All rights reserved.
FAU - Hosokawa, Masashi
AU  - Hosokawa M
AD  - Faculty of Fisheries Sciences, Hokkaido University, 3-1-1 Minato, Hakodate, 
      Hokkaido 041-8611, Japan. hoso@fish.hokudai.ac.jp
FAU - Miyashita, Tatsuya
AU  - Miyashita T
FAU - Nishikawa, Sho
AU  - Nishikawa S
FAU - Emi, Shingo
AU  - Emi S
FAU - Tsukui, Takayuki
AU  - Tsukui T
FAU - Beppu, Fumiaki
AU  - Beppu F
FAU - Okada, Tomoko
AU  - Okada T
FAU - Miyashita, Kazuo
AU  - Miyashita K
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100531
PL  - United States
TA  - Arch Biochem Biophys
JT  - Archives of biochemistry and biophysics
JID - 0372430
RN  - 0 (Adipokines)
RN  - 0 (Anti-Obesity Agents)
RN  - 0 (Blood Glucose)
RN  - 0 (Hypoglycemic Agents)
RN  - 0 (RNA, Messenger)
RN  - 0 (Xanthophylls)
RN  - 06O0TC0VSM (fucoxanthin)
SB  - IM
MH  - Adipokines/*genetics
MH  - Adipose Tissue, White/*drug effects/*metabolism/pathology
MH  - Animals
MH  - Anti-Obesity Agents/pharmacology
MH  - Blood Glucose/metabolism
MH  - Cell Line
MH  - Diabetes Complications/blood/*genetics/immunology/pathology
MH  - Female
MH  - Gene Expression Regulation/*drug effects
MH  - Hypoglycemic Agents/pharmacology
MH  - Macrophages/drug effects/immunology
MH  - Mice
MH  - Obesity/blood/*genetics/immunology/pathology
MH  - RNA, Messenger/genetics/metabolism
MH  - Xanthophylls/*pharmacology
EDAT- 2010/06/03 06:00
MHDA- 2010/11/11 06:00
CRDT- 2010/06/03 06:00
PHST- 2010/03/22 00:00 [received]
PHST- 2010/05/07 00:00 [revised]
PHST- 2010/05/27 00:00 [accepted]
PHST- 2010/06/03 06:00 [entrez]
PHST- 2010/06/03 06:00 [pubmed]
PHST- 2010/11/11 06:00 [medline]
AID - S0003-9861(10)00208-0 [pii]
AID - 10.1016/j.abb.2010.05.031 [doi]
PST - ppublish
SO  - Arch Biochem Biophys. 2010 Dec 1;504(1):17-25. doi: 10.1016/j.abb.2010.05.031. 
      Epub 2010 May 31.