PMID- 20515710
OWN - NLM
STAT- MEDLINE
DCOM- 20110228
LR  - 20211020
IS  - 1558-0032 (Electronic)
IS  - 1089-7771 (Print)
IS  - 1089-7771 (Linking)
VI  - 14
IP  - 6
DP  - 2010 Nov
TI  - Equivalent moving dipole localization of cardiac ectopic activity in a swine 
      model during pacing.
PG  - 1318-26
LID - 10.1109/TITB.2010.2051448 [doi]
AB  - Localization of the initial site of cardiac ectopic activity has direct clinical 
      benefits for treating focal cardiac arrhythmias. The aim of the present study is 
      to experimentally evaluate the performance of the equivalent moving dipole 
      technique on noninvasively localizing the origin of the cardiac ectopic activity 
      from the recorded body surface potential mapping (BSPM) data in a well-controlled 
      experimental setting. The cardiac ectopic activities were induced in four 
      well-controlled intact pigs by either single-site pacing or dual-site pacing 
      within the ventricles. In each pacing study, the initiation sites of cardiac 
      ectopic activity were localized by estimating the locations of a single moving 
      dipole (SMD) or two moving dipoles (TMDs) from the measured BSPM data and 
      compared with the precise pacing sites (PSs). For the single-site pacing, the 
      averaged SMD localization error was 18.6 +/- 3.8 mm over 16 sites, while the 
      averaged distance between the TMD locations and the two corresponding PSs was 
      slightly larger (24.9 +/- 6.2 mm over five pairs of sites), both occurring at the 
      onset of the QRS complex (10-25 ms following the pacing spike). The obtained SMD 
      trajectories originated near the stimulus site and then traversed across the 
      heart during the ventricular depolarization. The present experimental results 
      show that the initial location of the moving dipole can provide the approximate 
      site of origin of a cardiac ectopic activity in vivo, and that the migration of 
      the dipole can portray the passage of an ectopic beat across the heart.
FAU - Lai, Dakun
AU  - Lai D
AD  - Department of Biomedical Engineering, University of Minnesota, Minneapolis, MN 
      55455, USA.
FAU - Liu, Chenguang
AU  - Liu C
FAU - Eggen, Michael D
AU  - Eggen MD
FAU - Iaizzo, Paul A
AU  - Iaizzo PA
FAU - He, Bin
AU  - He B
LA  - eng
GR  - R01 HL080093/HL/NHLBI NIH HHS/United States
GR  - R01HL080093/HL/NHLBI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
DEP - 20100527
PL  - United States
TA  - IEEE Trans Inf Technol Biomed
JT  - IEEE transactions on information technology in biomedicine : a publication of the 
      IEEE Engineering in Medicine and Biology Society
JID - 9712259
SB  - IM
MH  - Algorithms
MH  - Animals
MH  - Body Surface Potential Mapping/*methods
MH  - Cardiac Complexes, Premature/*physiopathology
MH  - Cardiac Pacing, Artificial/*methods
MH  - Electrocardiography/methods
MH  - *Models, Cardiovascular
MH  - *Signal Processing, Computer-Assisted
MH  - Swine
MH  - Ventricular Function
PMC - PMC2948591
MID - NIHMS212566
EDAT- 2010/06/03 06:00
MHDA- 2011/03/01 06:00
PMCR- 2011/11/01
CRDT- 2010/06/03 06:00
PHST- 2010/06/03 06:00 [entrez]
PHST- 2010/06/03 06:00 [pubmed]
PHST- 2011/03/01 06:00 [medline]
PHST- 2011/11/01 00:00 [pmc-release]
AID - 10.1109/TITB.2010.2051448 [doi]
PST - ppublish
SO  - IEEE Trans Inf Technol Biomed. 2010 Nov;14(6):1318-26. doi: 
      10.1109/TITB.2010.2051448. Epub 2010 May 27.