PMID- 20517761
OWN - NLM
STAT- MEDLINE
DCOM- 20100820
LR  - 20100602
IS  - 1306-696X (Print)
IS  - 1306-696X (Linking)
VI  - 16
IP  - 2
DP  - 2010 Mar
TI  - Renal cytokine and histopathologic changes following acutely increased 
      intra-abdominal pressure: an animal study.
PG  - 103-7
AB  - BACKGROUND: The reason for acute renal failure (ARF) in abdominal compartment 
      syndrome (ACS) is thought to be due to the increase in renal venous pressure. In 
      this study, the changes in plasma and renal tissue cytokine levels and 
      histopathologic changes in renal tubular and glomerular cells were evaluated and 
      compared in a model of acute elevation in abdominal tension with different 
      pressures. METHODS: Eighteen Sprague-Dawley rats were randomly assigned into 
      three groups: Sham-operated rats and rats in Groups 1 and 2, in which 20 and 30 
      mmHg of intra-abdominal pressure (IAP) was applied for 60 minutes, respectively. 
      Left kidneys of the animals and intracardiac blood samples were taken at the end 
      of the procedures. Tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 
      (IL-6) levels were investigated in plasma and renal tissue samples. Renal tissues 
      were also evaluated for histopathologic changes. RESULTS: Renal tissue and plasma 
      TNF-alpha and IL-6 levels were found to be significantly increased when the 
      sham-operated group was compared to the study groups (p<0.05). Renal tissue 
      changes showed that the total histopathologic scores were significantly increased 
      in study groups compared to the sham-operated group (p<0.05); tubular changes 
      were more prominent than glomerular changes. CONCLUSION: Abdominal tension 
      linearly can cause renal tubular histopathologic changes. Cytokines may play a 
      role in ARF due to ACS.
FAU - Akbulut, Gokhan
AU  - Akbulut G
AD  - Department of General Surgery, Afyon Kocatepe University Faculty of Medicine, 
      Afyonkarahisar, Turkey. akbulutg@asia.com
FAU - Altindis, Mustafa
AU  - Altindis M
FAU - Aktepe, Fatma
AU  - Aktepe F
FAU - Serteser, Mustafa
AU  - Serteser M
FAU - Dilek, Osman Nuri
AU  - Dilek ON
LA  - eng
PT  - Journal Article
PL  - Turkey
TA  - Ulus Travma Acil Cerrahi Derg
JT  - Ulusal travma ve acil cerrahi dergisi = Turkish journal of trauma & emergency 
      surgery : TJTES
JID - 101274231
RN  - 0 (Cytokines)
RN  - 0 (Interleukin-6)
RN  - 0 (Tumor Necrosis Factor-alpha)
SB  - IM
MH  - Abdomen/*pathology/*surgery
MH  - Animals
MH  - Cytokines/*blood
MH  - Interleukin-6/*blood/metabolism
MH  - Kidney/cytology/metabolism/pathology
MH  - Kidney Tubules, Proximal/metabolism/*pathology
MH  - Pressure
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Stress, Mechanical
MH  - Tumor Necrosis Factor-alpha/blood
EDAT- 2010/06/03 06:00
MHDA- 2010/08/21 06:00
CRDT- 2010/06/03 06:00
PHST- 2010/06/03 06:00 [entrez]
PHST- 2010/06/03 06:00 [pubmed]
PHST- 2010/08/21 06:00 [medline]
PST - ppublish
SO  - Ulus Travma Acil Cerrahi Derg. 2010 Mar;16(2):103-7.