PMID- 20518896
OWN - NLM
STAT- MEDLINE
DCOM- 20100902
LR  - 20220321
IS  - 1440-1827 (Electronic)
IS  - 1320-5463 (Linking)
VI  - 60
IP  - 6
DP  - 2010 Jun
TI  - A novel approach to biliary tract pathology based on similarities to pancreatic 
      counterparts: is the biliary tract an incomplete pancreas?
PG  - 419-29
LID - 10.1111/j.1440-1827.2010.02543.x [doi]
AB  - There are peribiliary glands around the biliary tract, and these glands drain 
      into the bile duct lumen. Interestingly, small amounts of pancreatic exocrine 
      acini are intermingled with these glands. Experimental studies using animals 
      suggest that the biliary tract shows some potential for pancreatic 
      differentiation. It is noteworth that the biliary tract and pancreas have similar 
      pathological features. IgG4-related sclerosing cholangitis and autoimmune 
      pancreatitis are representative inflammatory diseases with similar features. 
      Intraductal papillary neoplasms are found in the biliary tract and also in the 
      pancreas: intraductal papillary neoplasm of the bile duct (IPNB) and intraductal 
      papillary mucinous neoplasm of the pancreas (IPMN). IPNB and IPMN share common 
      histologic and phenotypic features and biological behaviors. Interestingly, 
      mucinous cystic neoplasm (MCN) arises in both the pancreas and the hepatobiliary 
      system. Intraductal tubular neoplasia is found in both the biliary tract and 
      pancreas as well. Intraepithelial neoplasm is found in the biliary tract and 
      pancreas: biliary intraepithelial neoplasm (BilIN) and pancreatic intraepithelial 
      neoplasm (PanIN). BilIN and PanIN are followed by conventional invasive 
      adenocarcinoma, while IPNB and IPMN are followed by tubular adenocarcinoma and 
      mucinous carcinoma in both organs. Further study of the biliary tract's 
      pathophysiology based on its similarity to pancreatic counterparts is warranted.
FAU - Nakanuma, Yasuni
AU  - Nakanuma Y
AD  - Department of Human Pathology, Kanazawa University Graduate School of Medicine, 
      Kanazawa, Japan. pbcpsc@kenroku.kanazawau.ac.jp
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Australia
TA  - Pathol Int
JT  - Pathology international
JID - 9431380
SB  - IM
MH  - Animals
MH  - Bile Duct Diseases/*pathology/physiopathology
MH  - Bile Duct Neoplasms/genetics/pathology
MH  - Bile Ducts, Extrahepatic/pathology
MH  - Biliary Tract/*pathology
MH  - Carcinoma, Pancreatic Ductal/pathology
MH  - Humans
MH  - Pancreas/*pathology
MH  - Pancreatic Diseases/*pathology/physiopathology
MH  - Pancreatic Neoplasms/genetics/pathology
RF  - 57
EDAT- 2010/06/04 06:00
MHDA- 2010/09/03 06:00
CRDT- 2010/06/04 06:00
PHST- 2010/06/04 06:00 [entrez]
PHST- 2010/06/04 06:00 [pubmed]
PHST- 2010/09/03 06:00 [medline]
AID - PIN2543 [pii]
AID - 10.1111/j.1440-1827.2010.02543.x [doi]
PST - ppublish
SO  - Pathol Int. 2010 Jun;60(6):419-29. doi: 10.1111/j.1440-1827.2010.02543.x.