PMID- 20518899
OWN - NLM
STAT- MEDLINE
DCOM- 20100902
LR  - 20100603
IS  - 1440-1827 (Electronic)
IS  - 1320-5463 (Linking)
VI  - 60
IP  - 6
DP  - 2010 Jun
TI  - Histopathological and cytological examination of autopsy cases with multiple 
      organ dysfunction syndromes.
PG  - 443-51
LID - 10.1111/j.1440-1827.2010.02539.x [doi]
AB  - To evaluate the role of small scavenger receptor A (SRA)-positive (SRA(+)) cells 
      and large SRA(+) cells in the peripheral blood (PB) in the pathophysiological 
      mechanisms underlying multiple organ dysfunction syndromes (MODS), 24 autopsy 
      cases with MODS were examined. In addition to histopathological and 
      immunohistochemical examination, cytokine levels of cardiac blood, the SRA index 
      (number of small SRA(+) cells in 10 high power fields, upper limit <30), and 
      appearance of large SRA(+) cells in PB were examined. The SRA index exceeded 30 
      in all cases. Large SRA(+) cells and tumor necrosis factor (TNF)-alpha(+) cells 
      were detected in PB in all cases. Macrophage colony stimulating factor (M-CSF), 
      interleukin (IL)-6 and IL-8 levels exceeded the normal level in all cases, and 18 
      and 15 cases had TNF-alpha and IL-1beta levels above the normal threshold, 
      respectively. Lung injury and necrosis of cardiac myocyte were observed in all 
      cases. Neutrophils and platelets accumulated in the capillaries of injured organs 
      and endothelial cells were extensively injured. From these results, large SRA(+) 
      cells differentiated from monocytes in PB were considered to play an important 
      role in the development of MODS, and necrosis of cardiac myocytes together with 
      lung injury might be the leading cause of death in MODS patients.
FAU - Emura, Iwao
AU  - Emura I
AD  - Department of Surgical Pathology, Japanese Red Cross Nagaoka Hospital, Nagaoka 
      City, , Japan. emura@nagaoka.jrc.or.Jp
FAU - Usuda, Hiroyuki
AU  - Usuda H
LA  - eng
PT  - Journal Article
PL  - Australia
TA  - Pathol Int
JT  - Pathology international
JID - 9431380
RN  - 0 (Cytokines)
RN  - 0 (MSR1 protein, human)
RN  - 0 (Scavenger Receptors, Class A)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Autopsy
MH  - Cell Count
MH  - Cytokines/metabolism
MH  - Female
MH  - Humans
MH  - Lung Injury/complications/metabolism/pathology
MH  - Male
MH  - Middle Aged
MH  - Monocytes/metabolism/pathology
MH  - Multiple Organ Failure/complications/metabolism/*pathology
MH  - Myocytes, Cardiac/metabolism/pathology
MH  - Necrosis/metabolism/pathology
MH  - Scavenger Receptors, Class A/metabolism
EDAT- 2010/06/04 06:00
MHDA- 2010/09/03 06:00
CRDT- 2010/06/04 06:00
PHST- 2010/06/04 06:00 [entrez]
PHST- 2010/06/04 06:00 [pubmed]
PHST- 2010/09/03 06:00 [medline]
AID - PIN2539 [pii]
AID - 10.1111/j.1440-1827.2010.02539.x [doi]
PST - ppublish
SO  - Pathol Int. 2010 Jun;60(6):443-51. doi: 10.1111/j.1440-1827.2010.02539.x.