PMID- 2051905
OWN - NLM
STAT- MEDLINE
DCOM- 19910725
LR  - 20190918
IS  - 0106-9543 (Print)
IS  - 0106-9543 (Linking)
VI  - 11
IP  - 2
DP  - 1991 Apr
TI  - Clinicopathological study of lymphocyte attachment to endothelial cells 
      (endothelialitis) in various liver diseases.
PG  - 78-88
AB  - An attachment of lymphocytes to the vascular wall, a feature called 
      "endothelialitis" (ETL) or "endotheliitis", was investigated in various liver 
      biopsies, including acute hepatitis (AH), hepatic infectious mononucleosis (IM), 
      drug-induced hepatitis, alcoholic hepatitis and fibrosis, chronic persistent 
      hepatitis (CPH), chronic active hepatitis (CAH), liver cirrhosis (LC), primary 
      biliary cirrhosis (PBC), nonspecific reactive hepatitis (NSRH), and cases with a 
      variety of diseases having almost normal liver histology as control material. 
      Although ETL has been considered to be nearly pathognomic of graft-versus-host 
      disease (GVHD) and acute transplant rejection, ETL was found in both portal and 
      central veins with a variable incidence, not only in all categories of liver 
      diseases, but also in the control group. The incidence of central vein ETL was 
      significantly higher in AH, CAH, PBC, IM, alcoholic fibrosis, and NSRH than that 
      of the control group, and that of portal vein ETL was significantly higher in AH, 
      CPH, CAH, LC, PBC, IM, and alcoholic fibrosis. Even under the light microscope, 
      lymphocytes attached to the endothelial cells had irregular cytoplasmic processes 
      making contact with endothelial cells. Also lymphocytes located beneath the 
      endothelial lining were frequently found. When ETL-positive and -negative cases 
      in the same category were compared, the levels of serum glutamic oxaloacetic 
      transaminase (GOT) and glutamic pyruvic transaminase (GPT) were usually higher in 
      the ETL-positive group, and statistically significant differences were observed 
      in CPH, CAH, LC, PBC and NSRH. In chronic hepatitis, the occurrence of portal 
      vein ETL paralleled the histologic activity of portal inflammation, whereas 
      central vein endothelialitis was associated with active parenchymal inflammation 
      such as sinusoidal lymphocyte infiltration and spotty hepatocyte necrosis, 
      indicating that ETL may be a phenomenon more frequently associated with active 
      hepatic inflammation. Immunohistochemical observations revealed that about 70% of 
      lymphocytes attached to the endothelial cells were T cells, while about 10% were 
      B cells. These data indicate that ETL in the liver is not specifically 
      pathognomonic for GVHD and rejection of liver transplants, and is universally 
      found in a variety of liver diseases with a varying incidence and activity, 
      related to the activity of hepatic inflammation, portal vein ETL occurring in 
      relation to active portal inflammation and central vein ETL to parenchymal 
      inflammation. Thus ETL is considered to be an intimate T lymphocyte-endothelial 
      cell interaction universally associated with active hepatic inflammation; it may 
      be an important phenomenon leading to accumulation of cellular exudates and their 
      reaction at the site of antigen in the tissue.
FAU - Nonomura, A
AU  - Nonomura A
AD  - Pathology Section, Kanazawa University Hospital, School of Medicine, Japan.
FAU - Mizukami, Y
AU  - Mizukami Y
FAU - Matsubara, F
AU  - Matsubara F
FAU - Kobayashi, K
AU  - Kobayashi K
LA  - eng
PT  - Journal Article
PL  - Denmark
TA  - Liver
JT  - Liver
JID - 8200939
SB  - IM
MH  - Biopsy
MH  - Endothelium, Vascular/*pathology
MH  - Hepatic Veins/pathology
MH  - Humans
MH  - Liver/*pathology
MH  - Liver Diseases/*pathology
MH  - Lymphocytes/*pathology
MH  - Portal Vein/pathology
EDAT- 1991/04/01 00:00
MHDA- 1991/04/01 00:01
CRDT- 1991/04/01 00:00
PHST- 1991/04/01 00:00 [pubmed]
PHST- 1991/04/01 00:01 [medline]
PHST- 1991/04/01 00:00 [entrez]
AID - 10.1111/j.1600-0676.1991.tb00496.x [doi]
PST - ppublish
SO  - Liver. 1991 Apr;11(2):78-88. doi: 10.1111/j.1600-0676.1991.tb00496.x.