PMID- 20519088
OWN - NLM
STAT- MEDLINE
DCOM- 20100907
LR  - 20190516
IS  - 1239-9736 (Print)
IS  - 1239-9736 (Linking)
VI  - 69
IP  - 3
DP  - 2010 Jun
TI  - Clinical manifestations and risk factors of coronary artery disease in patients 
      with diabetes mellitus in western Siberia.
PG  - 278-84
AB  - OBJECTIVE: To compare the prevalence of cardiovascular risk factors and clinical 
      manifestations of coronary artery disease (CAD) between patients with type 2 
      diabetes mellitus (DM) and CAD who lived at northern latitudes vs. those who 
      resided at southern latitudes in the Tyumen region, western Siberia. STUDY 
      DESIGN: This retrospective study involved 382 patients with type 2 DM selected 
      from 8,573 patients with angiographic CAD (>50% stenosis). Out of the total, 243 
      patients were permanent residents at the high latitudes of the Tyumen region 
      ("northern patients"), and 139 patients were permanent residents in areas south 
      of the Tyumen region ("southern patients"). RESULTS: On average, northern 
      patients were younger than southern patients (53 vs. 57 years, respectively). The 
      odds ratio (OR) for living in the north was 2.1 (95% CI 0.99-4.53) for obesity 
      (BMI>or=30 kg/m2), 1.87 (95% CI 1.05-3.31) for smoking, 0.93 (95% CI 0.89-0.96) 
      per 1 year increase in age, 0.84 (95% CI 0.76-0.94) per 1 mmol/L increase of 
      fasting plasma glucose, and 1.15 (95% CI 1.04-1.28) per 1 mm increase of right 
      ventricular end-diastolic diameter. The proportion of patients with 3 or more CAD 
      risk factors was higher in the north. Most patients in both groups had a history 
      of myocardial infarction, severe angina in class III/IV as defined by the 
      Canadian Cardiovascular System (CCS), heart failure in class II/IV as defined by 
      the New York Heart Association (NYHA) and hypertension. CONCLUSIONS: A 
      north-south gradient was observed in cardiovascular risk factors among patients 
      with DM and CAD in the Tyumen region. The clinical manifestations of CAD in DM 
      patients at high latitudes were comparable with those of patients who reside 
      south of the Tyumen region of western Siberia, despite the younger age of 
      northern patients.
FAU - Kuznetsov, Vadim A
AU  - Kuznetsov VA
AD  - Tyumen Cardiology Center-branch of Institute of Cardiology, Russian Academy of 
      Medical Sciences, Siberian Branch, Tyumen, 625026, Russia. kuznets@tmn.ru
FAU - Yaroslavskaya, Elena I
AU  - Yaroslavskaya EI
FAU - Bessonova, Marina I
AU  - Bessonova MI
FAU - Bessonov, Ivan S
AU  - Bessonov IS
FAU - Zyrianov, Igor P
AU  - Zyrianov IP
FAU - Kolunin, Grigoriy V
AU  - Kolunin GV
FAU - Krinochkin, Dmitriy V
AU  - Krinochkin DV
FAU - Maryinskih, Luiza V
AU  - Maryinskih LV
FAU - Bektasheva, Anisa S
AU  - Bektasheva AS
LA  - eng
PT  - Journal Article
DEP - 20100526
PL  - United States
TA  - Int J Circumpolar Health
JT  - International journal of circumpolar health
JID - 9713056
SB  - IM
MH  - Coronary Angiography
MH  - Coronary Artery Disease/complications/*diagnosis
MH  - Diabetes Mellitus, Type 2/*complications/epidemiology
MH  - Echocardiography
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Risk Factors
MH  - Siberia/epidemiology
EDAT- 2010/06/04 06:00
MHDA- 2010/09/08 06:00
CRDT- 2010/06/04 06:00
PHST- 2010/06/04 06:00 [entrez]
PHST- 2010/06/04 06:00 [pubmed]
PHST- 2010/09/08 06:00 [medline]
AID - 1024 [pii]
AID - 10.3402/ijch.v69i3.17617 [doi]
PST - ppublish
SO  - Int J Circumpolar Health. 2010 Jun;69(3):278-84. doi: 10.3402/ijch.v69i3.17617. 
      Epub 2010 May 26.