PMID- 20519130
OWN - NLM
STAT- MEDLINE
DCOM- 20100909
LR  - 20211020
IS  - 1096-0953 (Electronic)
IS  - 0013-9351 (Print)
IS  - 0013-9351 (Linking)
VI  - 110
IP  - 6
DP  - 2010 Aug
TI  - Environmental toxins and risk of narcolepsy among people with HLA DQB1*0602.
PG  - 565-70
LID - 10.1016/j.envres.2010.05.002 [doi]
AB  - One etiologic model for narcolepsy suggests that some environmental toxin 
      selectively and irreversibly destroys hypocretin-producing cells in individuals 
      with human leukocyte antigen (HLA) DQB1(*)0602. Between 2001 and 2005, the 
      authors conducted a population-based case-control study in King County, 
      Washington to examine narcolepsy risk in relation to toxins found in jobs, 
      hobbies, and other non-vocational activities. Sixty-seven cases and 95 controls 
      were enrolled; all were between ages 18 and 50 and positive for HLA DQB1(*)0602. 
      All were administered in-person interviews about jobs, hobbies or other 
      non-vocational activities before age 21. All analyses were adjusted for 
      African-American race and income. Risk increased significantly for jobs involving 
      heavy metals (odds ratio [OR]=4.7; 95% confidence interval [CI]: 1.5, 14.5) and 
      for highest levels of exposure to woodwork (OR: 3.0; 95% CI: 1.0, 8.9), 
      fertilizer (OR=3.1; 95% CI: 1.1, 9.1), and bug or weed killer (OR=4.5; 95% CI: 
      1.5, 13.4). Associations were of borderline significance for activities involving 
      ceramics, pesticides, and painting projects. Significant dose-response 
      relationships were evident for jobs involving metals (p<0.03), paints (p<0.03), 
      and bug or weed killer (p<0.02). Additional studies are needed to replicate these 
      findings and continue the search for specific toxins that could damage hypocretin 
      neurons in genetically susceptible people.
CI  - Copyright 2010 Elsevier Inc. All rights reserved.
FAU - Ton, Thanh G N
AU  - Ton TG
AD  - Neuroepidemiology Group, University of Washington, Seattle, WA, USA. 
      thanhton@u.washington.edu
FAU - Longstreth, W T Jr
AU  - Longstreth WT Jr
FAU - Koepsell, Thomas D
AU  - Koepsell TD
LA  - eng
GR  - R01NS38523/NS/NINDS NIH HHS/United States
GR  - L30 NS052978-03/NS/NINDS NIH HHS/United States
GR  - R01 NS038523/NS/NINDS NIH HHS/United States
GR  - L30 NS052978-02/NS/NINDS NIH HHS/United States
GR  - L30 NS052978-04/NS/NINDS NIH HHS/United States
GR  - R01 NS038523-01A2/NS/NINDS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20100601
PL  - Netherlands
TA  - Environ Res
JT  - Environmental research
JID - 0147621
RN  - 0 (Environmental Pollutants)
RN  - 0 (HLA-DQ Antigens)
RN  - 0 (HLA-DQ beta-Chains)
RN  - 0 (HLA-DQB1 antigen)
RN  - 0 (Membrane Glycoproteins)
RN  - 0 (Metals, Heavy)
RN  - 0 (Pesticides)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Demography
MH  - Dose-Response Relationship, Drug
MH  - Environmental Exposure/*analysis/statistics & numerical data
MH  - Environmental Pollutants/*toxicity
MH  - Female
MH  - HLA-DQ Antigens/*metabolism
MH  - HLA-DQ beta-Chains
MH  - Humans
MH  - Male
MH  - Membrane Glycoproteins/*metabolism
MH  - Metals, Heavy/toxicity
MH  - Middle Aged
MH  - Narcolepsy/epidemiology/*etiology/metabolism
MH  - Pesticides/toxicity
MH  - Risk
MH  - Washington
MH  - Young Adult
PMC - PMC2930404
MID - NIHMS212156
EDAT- 2010/06/04 06:00
MHDA- 2010/09/10 06:00
PMCR- 2011/08/01
CRDT- 2010/06/04 06:00
PHST- 2009/07/21 00:00 [received]
PHST- 2010/04/21 00:00 [revised]
PHST- 2010/05/07 00:00 [accepted]
PHST- 2010/06/04 06:00 [entrez]
PHST- 2010/06/04 06:00 [pubmed]
PHST- 2010/09/10 06:00 [medline]
PHST- 2011/08/01 00:00 [pmc-release]
AID - S0013-9351(10)00069-1 [pii]
AID - 10.1016/j.envres.2010.05.002 [doi]
PST - ppublish
SO  - Environ Res. 2010 Aug;110(6):565-70. doi: 10.1016/j.envres.2010.05.002. Epub 2010 
      Jun 1.