PMID- 20519253
OWN - NLM
STAT- MEDLINE
DCOM- 20111201
LR  - 20220408
IS  - 1749-5024 (Electronic)
IS  - 1749-5016 (Print)
IS  - 1749-5016 (Linking)
VI  - 6
IP  - 4
DP  - 2011 Sep
TI  - Negative affectivity, self-referential processing and the cortical midline 
      structures.
PG  - 426-33
LID - 10.1093/scan/nsq049 [doi]
AB  - The neural bases of the association between negative affectivity and self-focus 
      remain unknown in healthy subjects. Building on the role of the cortical midline 
      structures (CMS) in self-referential processing, we hypothesized that negative 
      affectivity in healthy subjects would be associated with an increased activation 
      of the CMS during self-referential processing. We presented positive and negative 
      pictures to 45 healthy subjects during fMRI and asked them to judge whether the 
      pictures were related to themselves or not (self condition), or whether the 
      pictures were positive or negative (general condition). Negative affectivity was 
      measured by the level of harm avoidance (HA) with the Temperament and Character 
      Inventory. Self-referential processing activated the CMS, including the dorsal 
      and ventral medial prefrontal cortex (MPFC) and the posterior cingulate cortex 
      (PCC). A higher HA score was associated with a greater activation of the dorsal 
      MPFC and PCC during self-referential processing, this greater activation being 
      more pronounced for negative pictures in the dorsal MPFC. This increased 
      activation of the CMS may embody the association between negative affectivity and 
      self-focus in healthy subjects, as previously observed in major depression. 
      Within the CMS, the dorsal MPFC may play a key role in negative affectivity, 
      integrating an increased attention to negative stimuli with an increased 
      attention to the self.
FAU - Lemogne, Cedric
AU  - Lemogne C
AD  - CNRS USR 3246, Pitie-Salpetriere Hospital, 47 boulevard de l'Hopital, 75013 
      Paris, France. cedric-lemogne@orange.fr
FAU - Gorwood, Philip
AU  - Gorwood P
FAU - Bergouignan, Loretxu
AU  - Bergouignan L
FAU - Pelissolo, Antoine
AU  - Pelissolo A
FAU - Lehericy, Stephane
AU  - Lehericy S
FAU - Fossati, Philippe
AU  - Fossati P
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100602
PL  - England
TA  - Soc Cogn Affect Neurosci
JT  - Social cognitive and affective neuroscience
JID - 101288795
SB  - IM
MH  - Adult
MH  - Brain Mapping
MH  - Cerebral Cortex/*physiology
MH  - Emotions/*physiology
MH  - Fear/physiology
MH  - Female
MH  - Gyrus Cinguli/physiology
MH  - Humans
MH  - Image Processing, Computer-Assisted
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Personality Tests
MH  - Photic Stimulation
MH  - Prefrontal Cortex/physiology
MH  - Psychometrics
MH  - Temperament
MH  - Young Adult
PMC - PMC3150850
EDAT- 2010/06/04 06:00
MHDA- 2011/12/13 00:00
PMCR- 2012/09/01
CRDT- 2010/06/04 06:00
PHST- 2010/06/04 06:00 [entrez]
PHST- 2010/06/04 06:00 [pubmed]
PHST- 2011/12/13 00:00 [medline]
PHST- 2012/09/01 00:00 [pmc-release]
AID - nsq049 [pii]
AID - 10.1093/scan/nsq049 [doi]
PST - ppublish
SO  - Soc Cogn Affect Neurosci. 2011 Sep;6(4):426-33. doi: 10.1093/scan/nsq049. Epub 
      2010 Jun 2.