PMID- 20519748
OWN - NLM
STAT- MEDLINE
DCOM- 20100914
LR  - 20220310
IS  - 1470-7926 (Electronic)
IS  - 1351-0711 (Linking)
VI  - 67
IP  - 8
DP  - 2010 Aug
TI  - Outdoor air pollution is associated with rapid decline of lung function in 
      alpha-1-antitrypsin deficiency.
PG  - 556-61
LID - 10.1136/oem.2009.047589 [doi]
AB  - INTRODUCTION: Outdoor air pollutants are associated with respiratory morbidity 
      and mortality, but little longitudinal work has been undertaken in this area in 
      chronic obstructive pulmonary disease (COPD). Patients with alpha-1-antitrypsin 
      deficiency (AATD) typically exhibit faster decline of lung function than subjects 
      with usual COPD and thus represent a group in whom studies of factors influencing 
      decline may be more easily clarified. METHODS: Decline of FEV(1) and KCO in 
      subjects of the PiZZ genotype from the UK AATD registry were studied. Pollution 
      levels (PM(10), ozone, sulphur dioxide, nitrogen dioxide) during the exposure 
      window were extracted from GIS maps, matching the measurement to each patient's 
      home address. Clinical predictors of decline were sought using generalised 
      estimating equations, and pollutants added to these subsequently. Single 
      pollutant models were used due to multicollinearity. RESULTS: In the FEV(1) 
      decline analysis, higher baseline FEV(1) was associated with rapid decline of 
      FEV(1) (p<0.001). High PM(10) exposure predicted more rapid decline of FEV(1) 
      (p=0.024). In a similar analysis for KCO decline, higher baseline KCO predicted 
      rapid decline (p<0.001) as did higher exposure to ozone (p=0.018). High PM(10) 
      exposure also showed a trend towards this effect (p=0.056). CONCLUSIONS: Exposure 
      to ozone and PM(10) predicts decline of lung function in AATD.
FAU - Wood, Alice M
AU  - Wood AM
AD  - School of Medicine and Dental Sciences, University of Birmingham, Birmingham, UK.
FAU - Harrison, Roy M
AU  - Harrison RM
FAU - Semple, Sean
AU  - Semple S
FAU - Ayres, Jon G
AU  - Ayres JG
FAU - Stockley, Robert A
AU  - Stockley RA
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100602
PL  - England
TA  - Occup Environ Med
JT  - Occupational and environmental medicine
JID - 9422759
RN  - 0UZA3422Q4 (Sulfur Dioxide)
RN  - 66H7ZZK23N (Ozone)
SB  - IM
MH  - Air Pollution/*adverse effects
MH  - Female
MH  - Forced Expiratory Volume/physiology
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Occupational Exposure/*adverse effects
MH  - Ozone/*toxicity
MH  - Pulmonary Disease, Chronic Obstructive/epidemiology/*physiopathology
MH  - Respiratory Function Tests
MH  - Sulfur Dioxide/*toxicity
MH  - Surveys and Questionnaires
MH  - United Kingdom/epidemiology
MH  - alpha 1-Antitrypsin Deficiency/epidemiology/*physiopathology
EDAT- 2010/06/04 06:00
MHDA- 2010/09/16 06:00
CRDT- 2010/06/04 06:00
PHST- 2010/06/04 06:00 [entrez]
PHST- 2010/06/04 06:00 [pubmed]
PHST- 2010/09/16 06:00 [medline]
AID - oem.2009.047589 [pii]
AID - 10.1136/oem.2009.047589 [doi]
PST - ppublish
SO  - Occup Environ Med. 2010 Aug;67(8):556-61. doi: 10.1136/oem.2009.047589. Epub 2010 
      Jun 2.