PMID- 20519846
OWN - NLM
STAT- MEDLINE
DCOM- 20100923
LR  - 20191210
IS  - 1880-3989 (Electronic)
IS  - 0388-1350 (Linking)
VI  - 35
IP  - 3
DP  - 2010 Jun
TI  - Recreational drugs, 3,4-Methylenedioxymethamphetamine(MDMA), 
      3,4-methylenedioxyamphetamine (MDA) and diphenylprolinol, inhibit neurite 
      outgrowth in PC12 cells.
PG  - 375-81
AB  - 3,4-Methylenedioxymethamphetamine (MDMA) is widely abused as a psychoactive 
      recreational drug. It is well known that MDMA induces neurotoxic damage of 
      serotonergic nerve endings. Although drug abuse is increasing among youths, it is 
      unclear whether recreational drugs affect the development of nerve growth. Thus, 
      the present study examined the effect of recreational drugs, such as MDMA, 
      3,4-methylenedioxyamphetamine (MDA) and diphenylprolinol, a novel recreational 
      drug with a similar chemical structure as that of psychoactive agent pipradrol, 
      on nerve growth factor (NGF)-induced neurite outgrowth. These recreational drugs 
      induced a dose-dependent cell death in PC12 cells. The IC(50) values of MDMA, 
      MDA, R-diphenylprolinol and S-diphenylprolinol were 4.11 mM, 2.75 mM, 1.00 mM and 
      0.77 mM, respectively, at 24 hr. To examine the effects of these recreational 
      drugs on NGF-induced neurite outgrowth, PC12 cells were treated with NGF together 
      with MDMA, MDA, S-diphenylprolinol or R-diphenylprolinol at low toxic 
      concentrations. The recreational drugs significantly suppressed neurite outgrowth 
      of PC12 cells induced by NGF. The results suggest that these psychoactive 
      recreational drugs may inhibit neurite growth and thus be implicated in their 
      elicited neurotoxicity.
FAU - Kaizaki, Asuka
AU  - Kaizaki A
FAU - Tanaka, Sachiko
AU  - Tanaka S
FAU - Tsujikawa, Kenji
AU  - Tsujikawa K
FAU - Numazawa, Satoshi
AU  - Numazawa S
FAU - Yoshida, Takemi
AU  - Yoshida T
LA  - eng
PT  - Journal Article
PL  - Japan
TA  - J Toxicol Sci
JT  - The Journal of toxicological sciences
JID - 7805798
RN  - 0 (Illicit Drugs)
RN  - 4764-17-4 (3,4-Methylenedioxyamphetamine)
RN  - 9061-61-4 (Nerve Growth Factor)
RN  - 9DLQ4CIU6V (Proline)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
SB  - IM
MH  - 3,4-Methylenedioxyamphetamine/*toxicity
MH  - Animals
MH  - Depression, Chemical
MH  - Illicit Drugs/*toxicity
MH  - N-Methyl-3,4-methylenedioxyamphetamine/*toxicity
MH  - Nerve Growth Factor/pharmacology
MH  - Neurites/*drug effects/*physiology
MH  - PC12 Cells/*drug effects/physiology
MH  - Proline/*analogs & derivatives/*toxicity
MH  - Rats
EDAT- 2010/06/04 06:00
MHDA- 2010/09/24 06:00
CRDT- 2010/06/04 06:00
PHST- 2010/06/04 06:00 [entrez]
PHST- 2010/06/04 06:00 [pubmed]
PHST- 2010/09/24 06:00 [medline]
AID - JST.JSTAGE/jts/35.375 [pii]
AID - 10.2131/jts.35.375 [doi]
PST - ppublish
SO  - J Toxicol Sci. 2010 Jun;35(3):375-81. doi: 10.2131/jts.35.375.