PMID- 20522710
OWN - NLM
STAT- MEDLINE
DCOM- 20101102
LR  - 20210206
IS  - 1528-0020 (Electronic)
IS  - 0006-4971 (Linking)
VI  - 116
IP  - 10
DP  - 2010 Sep 9
TI  - Comparative analysis of predicted HLA binding of immunoglobulin idiotype 
      sequences indicates T cell-mediated immunosurveillance in follicular lymphoma.
PG  - 1734-6
LID - 10.1182/blood-2010-02-270199 [doi]
AB  - Active immunization with the idiotype of follicular lymphoma induces 
      tumor-specific immunity. T cells induced in vivo by idiotype vaccination 
      recognize human leukocyte antigen (HLA)--restricted hypervariable but not 
      conserved idiotype peptides. We hypothesized that idiotype-directed T-cell 
      immunity occurs naturally and performed a reverse immunology analysis of idiotype 
      HLA binding in 39 follicular lymphoma patients. For every idiotype, the sum of 
      HLA-A or -B binding scores of the 20 highest-scoring peptides was calculated for 
      all 39 HLA types through the BIMAS algorithm. The idiotype sum score of every 
      patient's lymphoma was compared on the respective patient's HLA type to the mean 
      of the sum scores of the remaining 38 idiotypes. Autologous idiotypes had lower 
      immunogenicity than allogeneic idiotypes. Differential immunogenicity resided 
      predominantly in all 3 complementarity-determining regions rather than in 
      framework peptides. Idiotype immunogenicity was not changed by somatic 
      hypermutation. These findings indicate T cell-mediated immunosurveillance of 
      follicular lymphoma directed specifically against individual idiotype epitopes.
FAU - Strothmeyer, Anna-Maria
AU  - Strothmeyer AM
AD  - Department of Hematology/Oncology, University Medical Center Freiburg, Freiburg, 
      Germany.
FAU - Papaioannou, Dimitrios
AU  - Papaioannou D
FAU - Duhren-von Minden, Marcus
AU  - Duhren-von Minden M
FAU - Navarrete, Marcelo
AU  - Navarrete M
FAU - Zirlik, Katja
AU  - Zirlik K
FAU - Heining-Mikesch, Kristina
AU  - Heining-Mikesch K
FAU - Veelken, Hendrik
AU  - Veelken H
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20100603
PL  - United States
TA  - Blood
JT  - Blood
JID - 7603509
RN  - 0 (Epitopes, T-Lymphocyte)
RN  - 0 (HLA Antigens)
RN  - 0 (HLA-A Antigens)
RN  - 0 (HLA-B Antigens)
RN  - 0 (Immunoglobulin Idiotypes)
SB  - IM
CIN - Blood. 2019 Feb 21;133(8):878-881. PMID: 30545830
MH  - Adult
MH  - Aged
MH  - Algorithms
MH  - Alleles
MH  - Epitopes, T-Lymphocyte/genetics/immunology/metabolism
MH  - Female
MH  - HLA Antigens/genetics/*immunology/metabolism
MH  - HLA-A Antigens/genetics/immunology/metabolism
MH  - HLA-B Antigens/genetics/immunology/metabolism
MH  - Humans
MH  - Immunoglobulin Idiotypes/genetics/*immunology/metabolism
MH  - Lymphoma, Follicular/genetics/*immunology/metabolism
MH  - Male
MH  - Middle Aged
MH  - Monitoring, Immunologic/statistics & numerical data
MH  - Protein Binding
MH  - T-Lymphocytes/cytology/*immunology/metabolism
EDAT- 2010/06/05 06:00
MHDA- 2010/11/03 06:00
CRDT- 2010/06/05 06:00
PHST- 2010/06/05 06:00 [entrez]
PHST- 2010/06/05 06:00 [pubmed]
PHST- 2010/11/03 06:00 [medline]
AID - S0006-4971(20)33027-5 [pii]
AID - 10.1182/blood-2010-02-270199 [doi]
PST - ppublish
SO  - Blood. 2010 Sep 9;116(10):1734-6. doi: 10.1182/blood-2010-02-270199. Epub 2010 
      Jun 3.