PMID- 20523828
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20110714
LR  - 20211020
IS  - 2005-3894 (Electronic)
IS  - 1013-9087 (Print)
IS  - 1013-9087 (Linking)
VI  - 21
IP  - 4
DP  - 2009 Nov
TI  - The Expression of NMDA Receptor 1 Correlates with Clinicopathological Parameters 
      in Cutaneous Squamous Cell Carcinoma.
PG  - 382-8
LID - 10.5021/ad.2009.21.4.382 [doi]
AB  - BACKGROUND: Ionotropic glutamate receptors of the N-methyl-D-aspartate receptor 
      (NMDAR) type are expressed on keratinocytes and play a role in the proliferation, 
      differentiation, and cornification of keratinocytes. However, the expression 
      profile of NMDAR and its role in cutaneous malignancy is unclear. OBJECTIVE: We 
      analyzed the expression of NMDAR-1 in cutaneous squamous cell carcinoma (SCC) and 
      investigated the relationship between NMDAR-1 expression and clinicopathological 
      parameters. METHODS: Thirty-two patients with biopsy-proven cutaneous SCC were 
      enrolled in this study. Each patient was analyzed for tumor diameter, location, 
      local recurrence, and metastasis by conducting a chart review. The SCC specimens 
      were histologically divided into differentiated and undifferentiated groups based 
      on Broders' system. NMDAR-1 expression was examined by performing 
      immunohistochemistry, and the relative staining intensity in the SCCs was graded 
      into 5 levels. According to the staining intensity of NMDAR-1, the specimens were 
      categorized into two groups: the higher group and the lower group. RESULTS: 
      Fifteen (88%) of 17 tumors in the higher group were differentiated SCC, whereas 
      14 (93%) of 15 tumors in the lower group were undifferentiated SCC. In addition, 
      NMDAR-1 expression was inversely correlated with metastasis (p=0.049). Local 
      recurrence was associated with a lower staining intensity, but the results were 
      not statistically significant. CONCLUSION: Our results demonstrate that NMDAR-1 
      expression in cutaneous SCC is significantly correlated with its differentiation 
      and metastasis. Therefore, it may be a prognostic indicator for cutaneous SCC.
FAU - Kang, Minju
AU  - Kang M
AD  - Department of Dermatology, College of Medicine, The Catholic University of Korea, 
      Seoul, Korea.
FAU - Cho, Jae Hoon
AU  - Cho JH
FAU - Koo, Ja Kyung
AU  - Koo JK
FAU - Noh, Sun Up
AU  - Noh SU
FAU - Kim, Mi-Yeon
AU  - Kim MY
FAU - Kang, Hoon
AU  - Kang H
FAU - Oh, Shin Taek
AU  - Oh ST
FAU - Kim, Hyung-Ok
AU  - Kim HO
FAU - Park, Young Min
AU  - Park YM
LA  - eng
PT  - Journal Article
DEP - 20091130
PL  - Korea (South)
TA  - Ann Dermatol
JT  - Annals of dermatology
JID - 8916577
PMC - PMC2861274
OTO - NOTNLM
OT  - Cutaneous squamous cell carcinoma
OT  - Differentiation
OT  - Metastasis
OT  - N-methyl-D-aspartate receptor
EDAT- 2010/06/05 06:00
MHDA- 2010/06/05 06:01
PMCR- 2009/11/01
CRDT- 2010/06/05 06:00
PHST- 2008/07/23 00:00 [received]
PHST- 2009/06/16 00:00 [revised]
PHST- 2009/06/17 00:00 [accepted]
PHST- 2010/06/05 06:00 [entrez]
PHST- 2010/06/05 06:00 [pubmed]
PHST- 2010/06/05 06:01 [medline]
PHST- 2009/11/01 00:00 [pmc-release]
AID - 10.5021/ad.2009.21.4.382 [doi]
PST - ppublish
SO  - Ann Dermatol. 2009 Nov;21(4):382-8. doi: 10.5021/ad.2009.21.4.382. Epub 2009 Nov 
      30.