PMID- 20525009 OWN - NLM STAT- MEDLINE DCOM- 20110325 LR - 20101214 IS - 1469-8986 (Electronic) IS - 0048-5772 (Linking) VI - 48 IP - 1 DP - 2011 Jan TI - Change-related responses in the human auditory cortex: an MEG study. PG - 23-30 LID - 10.1111/j.1469-8986.2010.01038.x [doi] AB - We recorded cortical activity in response to the onset, offset, and frequency change of a pure tone using magnetencephalograms (MEGs) to clarify the physiological significance of N1m relating to the detection of changes. Four interstimulus intervals (ISIs) (0.5, 1.5, 3, and 6 s) were used for each of the three auditory events. Results showed that (i) all three auditory events elicited N1m with a similar topography and similar temporal profile, (ii) the source of N1m was located in the superior temporal gyrus (STG) for all events under all ISI conditions, (iii) the amplitude of the STG activity as a function of the duration of the steady state preceding the change was similar among the three events, and (iv) there was a significant positive correlation in amplitude between on-N1m and off-N1m and between on-N1m and change-N1m. These results suggested that N1m for the three events has a similar physiological significance relating to the detection of changes. CI - Copyright (c) 2010 Society for Psychophysiological Research. FAU - Yamashiro, Koya AU - Yamashiro K AD - Department of Integrative Physiology, National Institute for Physiological Sciences, Okazaki, Japan. koya@nips.ac.jp FAU - Inui, Koji AU - Inui K FAU - Otsuru, Naofumi AU - Otsuru N FAU - Kakigi, Ryusuke AU - Kakigi R LA - eng PT - Journal Article PL - United States TA - Psychophysiology JT - Psychophysiology JID - 0142657 SB - IM MH - Acoustic Stimulation MH - Adult MH - Analysis of Variance MH - Auditory Cortex/*physiology MH - Auditory Perception/*physiology MH - Brain Mapping MH - Evoked Potentials, Auditory/*physiology MH - Female MH - Humans MH - Magnetoencephalography MH - Male MH - Middle Aged MH - Neurons/physiology MH - Regression Analysis EDAT- 2010/06/08 06:00 MHDA- 2011/03/26 06:00 CRDT- 2010/06/08 06:00 PHST- 2010/06/08 06:00 [entrez] PHST- 2010/06/08 06:00 [pubmed] PHST- 2011/03/26 06:00 [medline] AID - PSYP1038 [pii] AID - 10.1111/j.1469-8986.2010.01038.x [doi] PST - ppublish SO - Psychophysiology. 2011 Jan;48(1):23-30. doi: 10.1111/j.1469-8986.2010.01038.x.