PMID- 20525080
OWN - NLM
STAT- MEDLINE
DCOM- 20101014
LR  - 20211020
IS  - 1460-9568 (Electronic)
IS  - 0953-816X (Print)
IS  - 0953-816X (Linking)
VI  - 31
IP  - 9
DP  - 2010 May
TI  - Electrophysiological evidence of mediolateral functional dichotomy in the rat 
      nucleus accumbens during cocaine self-administration II: phasic firing patterns.
PG  - 1671-82
LID - 10.1111/j.1460-9568.2010.07230.x [doi]
AB  - In the cocaine self-administering rat, individual nucleus accumbens (NAcc) 
      neurons exhibit phasic changes in firing rate within minutes and/or seconds of 
      lever presses (i.e. slow phasic and rapid phasic changes, respectively). To 
      determine whether neurons that demonstrate these changes during 
      self-administration sessions are differentially distributed in the NAcc, rats 
      were implanted with jugular catheters and microwire arrays in different NAcc 
      subregions (core, dorsal shell, ventromedial shell, ventrolateral shell, or 
      rostral pole). Neural recording sessions were typically conducted on days 13-17 
      of cocaine self-administration (0.77 mg/kg per 0.2-mL infusion; fixed-ratio 1 
      schedule of reinforcement; 6-h daily sessions). Pre-press rapid phasic firing 
      rate changes were greater in lateral accumbal (core and ventrolateral shell) than 
      in medial accumbal (dorsal shell and rostral pole shell) subregions. Slow phasic 
      pattern analysis revealed that reversal latencies of neurons that exhibited 
      change + reversal patterns differed mediolaterally: medial NAcc neurons exhibited 
      more early reversals and fewer progressive/late reversals than lateral NAcc 
      neurons. Comparisons of firing patterns within individual neurons across time 
      bases indicated that lateral NAcc pre-press rapid phasic increases were 
      correlated with tonic increases. Tonic decreases were correlated with slow phasic 
      patterns in individual medial NAcc neurons, indicative of greater pharmacological 
      sensitivity of neurons in this region. On the other hand, the bias of the lateral 
      NAcc towards increased pre-press rapid phasic activity, coupled with a greater 
      prevalence of tonic increase firing, may reflect particular sensitivity of these 
      neurons to excitatory afferent signaling and perhaps differential pharmacological 
      influences on firing rates between regions.
FAU - Fabbricatore, Anthony T
AU  - Fabbricatore AT
AD  - Department of Psychology, Rutgers, the State University of New Jersey, 
      Piscataway, NJ 08854, USA. tonio@rci.rutgers.edu
FAU - Ghitza, Udi E
AU  - Ghitza UE
FAU - Prokopenko, Volodymyr F
AU  - Prokopenko VF
FAU - West, Mark O
AU  - West MO
LA  - eng
GR  - R01 DA006886/DA/NIDA NIH HHS/United States
GR  - R01 DA006886-13A2/DA/NIDA NIH HHS/United States
GR  - DA 006886/DA/NIDA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PL  - France
TA  - Eur J Neurosci
JT  - The European journal of neuroscience
JID - 8918110
RN  - 0 (Dopamine Uptake Inhibitors)
RN  - I5Y540LHVR (Cocaine)
SB  - IM
MH  - Action Potentials/*drug effects
MH  - Animals
MH  - Catheterization
MH  - Cocaine/administration & dosage/*pharmacology
MH  - Cocaine-Related Disorders/*physiopathology
MH  - Dopamine Uptake Inhibitors/administration & dosage/*pharmacology
MH  - Electrodes, Implanted
MH  - Male
MH  - Microelectrodes
MH  - Motor Activity/drug effects/physiology
MH  - Neurons/drug effects/physiology
MH  - Nucleus Accumbens/*drug effects/*physiopathology
MH  - Periodicity
MH  - Rats
MH  - Rats, Long-Evans
MH  - Self Administration
MH  - Time Factors
PMC - PMC3004470
MID - NIHMS212453
EDAT- 2010/06/09 06:00
MHDA- 2010/10/15 06:00
PMCR- 2011/05/01
CRDT- 2010/06/08 06:00
PHST- 2010/06/08 06:00 [entrez]
PHST- 2010/06/09 06:00 [pubmed]
PHST- 2010/10/15 06:00 [medline]
PHST- 2011/05/01 00:00 [pmc-release]
AID - EJN7230 [pii]
AID - 10.1111/j.1460-9568.2010.07230.x [doi]
PST - ppublish
SO  - Eur J Neurosci. 2010 May;31(9):1671-82. doi: 10.1111/j.1460-9568.2010.07230.x.