PMID- 20525153
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20110714
LR  - 20211020
IS  - 1710-1492 (Electronic)
IS  - 1710-1484 (Print)
IS  - 1710-1484 (Linking)
VI  - 2
IP  - 3
DP  - 2006 Sep 15
TI  - Coaggregation of FcepsilonRI with FcgammaRIIB Inhibits Degranulation but Not 
      Induction of Bcl-2 Family Members A1 and Bim in Mast Cells.
PG  - 87-97
LID - 10.1186/1710-1492-2-3-87 [doi]
AB  - : The aggregation of high-affinity immunoglobulin E (IgE) receptors (FcepsilonRI) 
      on mast cells is a critical event in the initiation of an allergic reaction. 
      Coengagement of FcepsilonRI with immunoglobulin G (IgG) low-affinity receptor 
      FcgammaRIIB/CD32 inhibits degranulation and the release of inflammatory mediators 
      from mast cells and has therefore been proposed as a new therapeutic approach for 
      the treatment of allergies. In this study, we investigated whether FcgammaRIIB, 
      besides inhibiting degranulation, negatively regulates other signalling pathways 
      downstream of FcepsilonRI. For this, we determined the phosphorylation and/or 
      expression of proteins involved in the regulation of mast-cell apoptosis. 
      Coaggregation led to an attenuation of Akt phosphorylation but did not inhibit 
      phosphorylation of transcription factor Foxo3a or its proapoptotic target, Bim. 
      Similarly, FcepsilonRI-dependent expression of the prosurvival gene A1 was not 
      affected by coaggregation. Our data demonstrate that coengagement of FcepsilonRI 
      and FcgammaRIIB inhibits degranulation but not the signalling pathways regulating 
      Bcl-2 family members Bim and A1.
FAU - Ekoff, Maria
AU  - Ekoff M
AD  - Department of Medicine, Clinical Immunology and Allergy Unit, Karolinska 
      Institutet, Stockholm, Sweden.
FAU - Moller, Christine
AU  - Moller C
FAU - Xiang, Zou
AU  - Xiang Z
FAU - Nilsson, Gunnar
AU  - Nilsson G
LA  - eng
PT  - Journal Article
DEP - 20060915
PL  - England
TA  - Allergy Asthma Clin Immunol
JT  - Allergy, asthma, and clinical immunology : official journal of the Canadian 
      Society of Allergy and Clinical Immunology
JID - 101244313
PMC - PMC2876181
EDAT- 2006/09/15 00:00
MHDA- 2006/09/15 00:01
PMCR- 2006/09/15
CRDT- 2010/06/08 06:00
PHST- 2010/06/08 06:00 [entrez]
PHST- 2006/09/15 00:00 [pubmed]
PHST- 2006/09/15 00:01 [medline]
PHST- 2006/09/15 00:00 [pmc-release]
AID - 1710-1492-2-3-87 [pii]
AID - 10.1186/1710-1492-2-3-87 [doi]
PST - ppublish
SO  - Allergy Asthma Clin Immunol. 2006 Sep 15;2(3):87-97. doi: 
      10.1186/1710-1492-2-3-87. Epub 2006 Sep 15.