PMID- 20525158
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121002
LR  - 20211020
IS  - 1710-1492 (Electronic)
IS  - 1710-1484 (Print)
IS  - 1710-1484 (Linking)
VI  - 2
IP  - 2
DP  - 2006 Jun 15
TI  - Lack of Correlation between Severity of Clinical Symptoms, Skin Test Reactivity, 
      and Radioallergosorbent Test Results in Venom-Allergic Patients.
PG  - 62-7
LID - 10.1186/1710-1492-2-2-62 [doi]
AB  - PURPOSE: To retrospectively examine the relation between skin test reactivity, 
      venom-specific immunoglobulin E (IgE) antibody levels, and severity of clinical 
      reaction in patients with insect venom allergy. METHOD: Thirty-six patients 
      (including 15 females) who presented with a history of allergic reactions to 
      insect stings were assessed. The mean age at the time of the reactions was 33.4 
      +/- 15.1 years (range, 4-76 years), and patients were evaluated 43.6 +/- 90 
      months (range, 1-300 months) after the reactions. Clinical reactions were scored 
      according to severity, from 1 (cutaneous manifestations only) to 3 (anaphylaxis 
      with shock). These scores were compared to scores for skin test reactivity (0 to 
      5, indicating the log increase in sensitivity from 1 mug/mL to 0.0001 mug/mL) and 
      radioallergosorbent test (RAST) levels (0 to 4, indicating venom-specific IgE 
      levels, from undetectable to >17.5 kilounits of antigen per litre [kUA/L]). 
      RESULTS: No correlation was found between skin test reactivity (Spearman's 
      coefficient = 0.15, p = .377) or RAST level (Spearman's coefficient = 0.32, p = 
      .061) and the severity of reaction. Skin test and RAST scores both differed 
      significantly from clinical severity (p < .05), but there was a significant 
      correlation between skin test reactivity and RAST score (p = .042). There was no 
      correlation between skin test reactivity and time since reaction (Spearman's 
      coefficient = 0.18, p = .294) nor between RAST and time since reaction (r = 
      0.1353, p = .438). Elimination of patients tested more than 12 months after their 
      reaction still produced no correlation between skin test reactivity (p = .681) or 
      RAST score (p = .183) and the severity of the clinical reaction. CONCLUSION: In 
      venom-allergic patients (in contrast to reported findings in cases of inhalant 
      IgE-mediated allergy), there appears to be no significant correlation between the 
      degree of skin test reactivity or levels of venom-specific IgE (determined by 
      RAST) and the severity of the clinical reaction.
FAU - Warrington, Rj
AU  - Warrington R
AD  - Departments of Medicine and Immunology, University of Manitoba, Winnipeg, 
      Manitoba. rwarrington@hsc.mb.ca.
LA  - eng
PT  - Journal Article
DEP - 20060615
PL  - England
TA  - Allergy Asthma Clin Immunol
JT  - Allergy, asthma, and clinical immunology : official journal of the Canadian 
      Society of Allergy and Clinical Immunology
JID - 101244313
PMC - PMC2876184
EDAT- 2006/06/15 00:00
MHDA- 2006/06/15 00:01
PMCR- 2006/06/15
CRDT- 2010/06/08 06:00
PHST- 2010/06/08 06:00 [entrez]
PHST- 2006/06/15 00:00 [pubmed]
PHST- 2006/06/15 00:01 [medline]
PHST- 2006/06/15 00:00 [pmc-release]
AID - 1710-1492-2-2-62 [pii]
AID - 10.1186/1710-1492-2-2-62 [doi]
PST - ppublish
SO  - Allergy Asthma Clin Immunol. 2006 Jun 15;2(2):62-7. doi: 
      10.1186/1710-1492-2-2-62. Epub 2006 Jun 15.