PMID- 20525189
OWN - NLM
STAT- MEDLINE
DCOM- 20101028
LR  - 20220318
IS  - 1756-9966 (Electronic)
IS  - 0392-9078 (Print)
IS  - 0392-9078 (Linking)
VI  - 29
IP  - 1
DP  - 2010 Jun 2
TI  - Vasculogenic mimicry contributes to lymph node metastasis of laryngeal squamous 
      cell carcinoma.
PG  - 60
LID - 10.1186/1756-9966-29-60 [doi]
AB  - BACKGROUND: Survival of laryngeal squamous cell carcinoma (LSCC) patients has 
      remained unchanged over recent years due to its uncontrolled recurrence and local 
      lymph node metastasis. Vasculogenic mimicry (VM) is an alternative type of blood 
      supplement related to more aggressive tumor biology and increased tumor-related 
      mortality. This study aimed to investigate the unique role of VM in the 
      progression of LSCC. METHODS: We reviewed clinical pathological data of 203 cases 
      of LSCC both prospectively and retrospectively. VM and endothelium-dependent 
      vessel (EDV) were detected by immunohistochemistry and double staining to compare 
      their different clinical pathological significance in LSCC. Survival analyses 
      were performed to assess their prognostic significance as well. RESULTS: Both VM 
      and EDV existed in LSCC type of blood supply. VM is related to pTNM stage, lymph 
      node metastasis and pathology grade. In contrust, EDV related to location, pTNM 
      stage, T stage and distant metastasis. Univariate analysis showed VM, pTNM stage, 
      T classification, nodal status, histopathological grade, tumor size, and 
      radiotherapy to be related to overall survival (OS). While, VM, location, tumor 
      size and radiotherapy were found to relate to disease free survival (DFS). 
      Multivariate analysis indicated that VM, but not EDV, was an adverse predictor 
      for both OS and DFS. CONCLUSIONS: VM existed in LSCC. It contributed to the 
      progression of LSCC by promoting lymph node metastasis. It is an independent 
      predictors of a poor prognosis of LSCC.
FAU - Wang, Wei
AU  - Wang W
AD  - Department of Pathology, Tianjin Cancer Hospital, Tianjin Medical University, 
      Tianjin 300060, PR China.
FAU - Lin, Peng
AU  - Lin P
FAU - Han, Chunrong
AU  - Han C
FAU - Cai, Wenjuan
AU  - Cai W
FAU - Zhao, Xiulan
AU  - Zhao X
FAU - Sun, Baocun
AU  - Sun B
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100602
PL  - England
TA  - J Exp Clin Cancer Res
JT  - Journal of experimental & clinical cancer research : CR
JID - 8308647
SB  - IM
MH  - Adult
MH  - Aged
MH  - Carcinoma, Squamous Cell/*blood supply/metabolism/pathology
MH  - Endothelium, Vascular/*pathology
MH  - Female
MH  - Humans
MH  - Immunoenzyme Techniques
MH  - Laryngeal Neoplasms/*blood supply/metabolism/pathology
MH  - Lymph Nodes
MH  - Lymphatic Metastasis
MH  - Male
MH  - Middle Aged
MH  - *Molecular Mimicry
MH  - Neoplasm Staging
MH  - *Neovascularization, Pathologic
MH  - Prognosis
MH  - Prospective Studies
MH  - Retrospective Studies
MH  - Survival Rate
PMC - PMC2887782
EDAT- 2010/06/08 06:00
MHDA- 2010/10/29 06:00
PMCR- 2010/06/02
CRDT- 2010/06/08 06:00
PHST- 2010/03/06 00:00 [received]
PHST- 2010/06/02 00:00 [accepted]
PHST- 2010/06/08 06:00 [entrez]
PHST- 2010/06/08 06:00 [pubmed]
PHST- 2010/10/29 06:00 [medline]
PHST- 2010/06/02 00:00 [pmc-release]
AID - 1756-9966-29-60 [pii]
AID - 10.1186/1756-9966-29-60 [doi]
PST - epublish
SO  - J Exp Clin Cancer Res. 2010 Jun 2;29(1):60. doi: 10.1186/1756-9966-29-60.