PMID- 20525506
OWN - NLM
STAT- MEDLINE
DCOM- 20100914
LR  - 20100607
IS  - 1557-8259 (Electronic)
IS  - 0030-6665 (Linking)
VI  - 43
IP  - 3
DP  - 2010 Jun
TI  - Local and systemic IgE in the evaluation and treatment of allergy.
PG  - 503-20, viii
LID - 10.1016/j.otc.2010.02.009 [doi]
AB  - Traditional descriptions of type I hypersensitivity and its manifestations center 
      on systemic immunoglobulin E (IgE)-mediated reactions to inciting antigens. 
      Hence, many current diagnostic and therapeutic measures are based on systemic 
      skin testing for allergy, systemic pharmacotherapy, and immunotherapy. Recent 
      developments in rhinology and pulmonology, particularly in defining the 
      phenomenon of local IgE production in various airway inflammatory conditions, 
      have an impact on both medical and surgical diagnosis and management of these 
      conditions. This review includes a discussion of allergy as a systemic disease, 
      current systemic diagnostic and management strategies for allergy, and local IgE 
      presence and synthesis in the upper and lower airways.
CI  - Copyright 2010 Elsevier Inc. All rights reserved.
FAU - Hoddeson, Elizabeth K
AU  - Hoddeson EK
AD  - Department of Otolaryngology-Head and Neck Surgery, Emory University, 1365A 
      Clifton Road NE, Suite A2300, Atlanta, GA 30322, USA.
FAU - Pratt, Eleanor
AU  - Pratt E
FAU - Harvey, Richard J
AU  - Harvey RJ
FAU - Wise, Sarah K
AU  - Wise SK
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Otolaryngol Clin North Am
JT  - Otolaryngologic clinics of North America
JID - 0144042
RN  - 0 (Anti-Inflammatory Agents)
RN  - 0 (Cytokines)
RN  - 0 (Histamine Antagonists)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Administration, Intranasal
MH  - Administration, Topical
MH  - Anti-Inflammatory Agents/therapeutic use
MH  - Asthma/drug therapy/immunology
MH  - B-Lymphocytes/immunology
MH  - Cytokines/immunology
MH  - Histamine Antagonists/*therapeutic use
MH  - Humans
MH  - Immunoglobulin E/*immunology
MH  - Immunotherapy/methods
MH  - Lung/immunology
MH  - Rhinitis, Allergic, Perennial/drug therapy/*immunology/*therapy
RF  - 83
EDAT- 2010/06/09 06:00
MHDA- 2010/09/15 06:00
CRDT- 2010/06/08 06:00
PHST- 2010/06/08 06:00 [entrez]
PHST- 2010/06/09 06:00 [pubmed]
PHST- 2010/09/15 06:00 [medline]
AID - S0030-6665(10)00040-X [pii]
AID - 10.1016/j.otc.2010.02.009 [doi]
PST - ppublish
SO  - Otolaryngol Clin North Am. 2010 Jun;43(3):503-20, viii. doi: 
      10.1016/j.otc.2010.02.009.