PMID- 20526344
OWN - NLM
STAT- MEDLINE
DCOM- 20100907
LR  - 20211020
IS  - 1529-2916 (Electronic)
IS  - 1529-2908 (Linking)
VI  - 11
IP  - 7
DP  - 2010 Jul
TI  - An immunoglobulin-like receptor, Allergin-1, inhibits immunoglobulin E-mediated 
      immediate hypersensitivity reactions.
PG  - 601-7
LID - 10.1038/ni.1886 [doi]
AB  - Anaphylaxis is a life-threatening immediate hypersensitivity reaction triggered 
      by antigen capture by immunoglobulin E (IgE) bound to the high-affinity IgE 
      receptor (FcvarepsilonRI) on mast cells. However, the regulatory mechanism of 
      mast cell activation is not completely understood. Here we identify an 
      immunoglobulin-like receptor, Allergin-1, that contains an immunoreceptor 
      tyrosine-based inhibitory motif (ITIM)-like domain, and show it was 
      preferentially expressed on mast cells. Mouse Allergin-1 recruited the tyrosine 
      phosphatases SHP-1 and SHP-2 and the inositol phosphatase SHIP. Coligation of 
      Allergin-1 and FcvarepsilonRI suppressed IgE-mediated degranulation of bone 
      marrow-derived cultured mast cells. Moreover, mice deficient in Allergin-1 
      developed enhanced passive systemic and cutaneous anaphylaxis. Thus, Allergin-1 
      suppresses IgE-mediated, mast cell-dependent anaphylaxis in mice.
FAU - Hitomi, Kaori
AU  - Hitomi K
AD  - Department of Immunology, Institute of Basic Medical Sciences, Graduate School of 
      Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Japan.
FAU - Tahara-Hanaoka, Satoko
AU  - Tahara-Hanaoka S
FAU - Someya, Satoru
AU  - Someya S
FAU - Fujiki, Akira
AU  - Fujiki A
FAU - Tada, Hideaki
AU  - Tada H
FAU - Sugiyama, Tetsuya
AU  - Sugiyama T
FAU - Shibayama, Shiro
AU  - Shibayama S
FAU - Shibuya, Kazuko
AU  - Shibuya K
FAU - Shibuya, Akira
AU  - Shibuya A
LA  - eng
SI  - GENBANK/AB542950
SI  - GENBANK/AB542951
SI  - GENBANK/AB542952
SI  - GENBANK/AB542953
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100606
PL  - United States
TA  - Nat Immunol
JT  - Nature immunology
JID - 100941354
RN  - 0 (Milr1 protein, mouse)
RN  - 0 (Receptors, IgE)
RN  - 0 (Receptors, Immunologic)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - EC 3.1.3.2 (Phosphoric Monoester Hydrolases)
RN  - EC 3.1.3.48 (Protein Tyrosine Phosphatase, Non-Receptor Type 11)
RN  - EC 3.1.3.48 (Protein Tyrosine Phosphatase, Non-Receptor Type 6)
RN  - EC 3.1.3.56 (Inositol Polyphosphate 5-Phosphatases)
SB  - IM
MH  - Amino Acid Sequence
MH  - Animals
MH  - Bone Marrow Cells/pathology
MH  - *Cell Degranulation
MH  - Cells, Cultured
MH  - Humans
MH  - Hypersensitivity, Immediate/genetics/*immunology/metabolism
MH  - Immunoglobulin E/metabolism
MH  - Inositol Polyphosphate 5-Phosphatases
MH  - Mast Cells/immunology/*metabolism/pathology
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Mice, Knockout
MH  - Molecular Sequence Data
MH  - Passive Cutaneous Anaphylaxis/*immunology
MH  - Phosphoric Monoester Hydrolases/metabolism
MH  - Protein Tyrosine Phosphatase, Non-Receptor Type 11/metabolism
MH  - Protein Tyrosine Phosphatase, Non-Receptor Type 6/metabolism
MH  - Receptor Aggregation/immunology
MH  - Receptors, IgE/metabolism
MH  - Receptors, Immunologic/chemistry/genetics/immunology/*metabolism
EDAT- 2010/06/08 06:00
MHDA- 2010/09/08 06:00
CRDT- 2010/06/08 06:00
PHST- 2010/03/23 00:00 [received]
PHST- 2010/05/13 00:00 [accepted]
PHST- 2010/06/08 06:00 [entrez]
PHST- 2010/06/08 06:00 [pubmed]
PHST- 2010/09/08 06:00 [medline]
AID - ni.1886 [pii]
AID - 10.1038/ni.1886 [doi]
PST - ppublish
SO  - Nat Immunol. 2010 Jul;11(7):601-7. doi: 10.1038/ni.1886. Epub 2010 Jun 6.