PMID- 20527796
OWN - NLM
STAT- MEDLINE
DCOM- 20101012
LR  - 20211020
IS  - 1520-510X (Electronic)
IS  - 0020-1669 (Linking)
VI  - 49
IP  - 13
DP  - 2010 Jul 5
TI  - Recent applications of a synthetic model of cytochrome c oxidase: beyond 
      functional modeling.
PG  - 5798-810
LID - 10.1021/ic100472p [doi]
AB  - This account reports recent developments of a functional model for the active 
      site of cytochrome c oxidase (CcO). This CcO mimic not only performs the 
      selective four-electron reduction of oxygen to water but also catalytically 
      reduces oxygen using the biological one-electron reductant, cytochrome c. This 
      functional model has been used to understand other biological reactions of CcO, 
      for example, the interaction between the gaseous hormone, NO, and CcO. A 
      mechanism for inactivating NO-CcO complexes is found to involve a reaction 
      between oxygen and Cu(B). Moreover, NO is shown to be capable of protecting CcO 
      from toxic inhibitors such as CN(-) and CO. Finally, this functional CcO model 
      has been used to show how H(2)S could induce hibernation by reversibly inhibiting 
      the oxygen binding step involved in respiration.
FAU - Collman, James P
AU  - Collman JP
AD  - Department of Chemistry, Stanford University, Stanford, California 94305, USA. 
      jpc@stanford.edu
FAU - Ghosh, Somdatta
AU  - Ghosh S
LA  - eng
GR  - R01 GM017880/GM/NIGMS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PL  - United States
TA  - Inorg Chem
JT  - Inorganic chemistry
JID - 0366543
RN  - 0 (Imidazoles)
RN  - 0 (Organometallic Compounds)
RN  - 0 (Porphyrins)
RN  - 9007-43-6 (Cytochromes c)
RN  - EC 1.9.3.1 (Electron Transport Complex IV)
SB  - IM
MH  - Biomimetic Materials/chemistry
MH  - Catalytic Domain
MH  - Cytochromes c/metabolism
MH  - Electron Transport Complex IV/*chemistry/metabolism
MH  - Imidazoles/chemical synthesis/*chemistry/metabolism
MH  - Kinetics
MH  - Models, Chemical
MH  - Models, Molecular
MH  - Organometallic Compounds/chemical synthesis/*chemistry/metabolism
MH  - Oxidation-Reduction
MH  - Porphyrins/chemical synthesis/*chemistry/metabolism
RF  - 51
EDAT- 2010/06/10 06:00
MHDA- 2010/10/13 06:00
CRDT- 2010/06/10 06:00
PHST- 2010/06/10 06:00 [entrez]
PHST- 2010/06/10 06:00 [pubmed]
PHST- 2010/10/13 06:00 [medline]
AID - 10.1021/ic100472p [doi]
PST - ppublish
SO  - Inorg Chem. 2010 Jul 5;49(13):5798-810. doi: 10.1021/ic100472p.