PMID- 20528954
OWN - NLM
STAT- MEDLINE
DCOM- 20110208
LR  - 20101102
IS  - 1601-183X (Electronic)
IS  - 1601-183X (Linking)
VI  - 9
IP  - 7
DP  - 2010 Oct
TI  - Lack of promoter IV-driven BDNF transcription results in depression-like 
      behavior.
PG  - 712-21
LID - 10.1111/j.1601-183X.2010.00605.x [doi]
AB  - Transcription of Bdnf is controlled by multiple promoters, in which promoter IV 
      contributes significantly to activity-dependent Bdnf transcription. We have 
      generated promoter IV mutant mice [brain-derived neurotrophic factor (BDNF)-KIV] 
      in which promoter IV-driven expression of BDNF is selectively disrupted by 
      inserting a green fluorescent protein (GFP)-STOP cassette within the Bdnf exon IV 
      locus. BDNF-KIV animals exhibited depression-like behavior as shown by the tail 
      suspension test (TST), sucrose preference test (SPT) and learned helplessness 
      test (LHT). In addition, BDNF-KIV mice showed reduced activity in the open field 
      test (OFT) and reduced food intake in the novelty-suppressed feeding test (NSFT). 
      The mutant mice did not display anxiety-like behavior in the light and dark box 
      test and elevated plus maze tests. Interestingly, the mutant mice showed 
      defective response inhibition in the passive avoidance test (PAT) even though 
      their learning ability was intact when measured with the active avoidance test 
      (AAT). These results suggest that promoter IV-dependent BDNF expression plays a 
      critical role in the control of mood-related behaviors. This is the first study 
      that directly addressed the effects of endogenous promoter-driven expression of 
      BDNF in depression-like behavior.
CI  - (c) 2010 The Authors. Genes, Brain and Behavior (c) 2010 Blackwell Publishing Ltd and 
      International Behavioural and Neural Genetics Society.
FAU - Sakata, K
AU  - Sakata K
AD  - Department of Pharmacology, University of Tennessee Health Science Center, 
      Memphis, TN 38163, USA. ksakata@uthsc.edu
FAU - Jin, L
AU  - Jin L
FAU - Jha, S
AU  - Jha S
LA  - eng
PT  - Journal Article
DEP - 20100705
PL  - England
TA  - Genes Brain Behav
JT  - Genes, brain, and behavior
JID - 101129617
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 147336-22-9 (Green Fluorescent Proteins)
RN  - 57-50-1 (Sucrose)
SB  - IM
MH  - Animals
MH  - Anxiety/genetics/psychology
MH  - Avoidance Learning/physiology
MH  - Brain-Derived Neurotrophic Factor/*biosynthesis/*genetics
MH  - Darkness
MH  - Depression/*genetics/*psychology
MH  - Eating/physiology
MH  - Environment
MH  - Food Preferences/physiology/psychology
MH  - Green Fluorescent Proteins/genetics
MH  - Helplessness, Learned
MH  - Hindlimb Suspension/psychology
MH  - Light
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Mice, Knockout
MH  - Motor Activity/physiology
MH  - Promoter Regions, Genetic/*genetics
MH  - Sucrose/pharmacology
MH  - Swimming/psychology
EDAT- 2010/06/10 06:00
MHDA- 2011/02/09 06:00
CRDT- 2010/06/10 06:00
PHST- 2010/06/10 06:00 [entrez]
PHST- 2010/06/10 06:00 [pubmed]
PHST- 2011/02/09 06:00 [medline]
AID - GBB605 [pii]
AID - 10.1111/j.1601-183X.2010.00605.x [doi]
PST - ppublish
SO  - Genes Brain Behav. 2010 Oct;9(7):712-21. doi: 10.1111/j.1601-183X.2010.00605.x. 
      Epub 2010 Jul 5.