PMID- 20529261
OWN - NLM
STAT- MEDLINE
DCOM- 20100924
LR  - 20240318
IS  - 1471-2342 (Electronic)
IS  - 1471-2342 (Linking)
VI  - 10
DP  - 2010 Jun 7
TI  - In-vivo high resolution imaging of optic nerve head drusen using spectral-domain 
      Optical Coherence Tomography.
PG  - 11
LID - 10.1186/1471-2342-10-11 [doi]
AB  - BACKGROUND: Optic nerve head drusen (ONHD) are white calcareous deposits, seen 
      either superficially on the optic nerve head or buried within it. Diagnosis of 
      ONHD is made by one or more ways: clinical exam, autofluorescence, ultrasound of 
      the optic nerve, CT scan and/or visual field examination. The present study 
      describes features of ONHD based on another diagnostic modality, the 
      spectral-domain OCT (Spectralis). METHODS: This is a retrospective case series of 
      5 patients with bilateral ONHD with a best-corrected visual acuity of 20/20 and 
      no other posterior segment pathology. All the patients underwent fundus 
      photography, fundus autofluorescence, B-scan ultrasonography, Spectralis OCT and 
      Humphrey 30-2 threshold visual fields. RESULTS: All 5 patients had surface ONHD 
      which were autofluorescent and echodense on B-scan ultrasonography. Spectralis 
      OCT findings in the corresponding areas include 'scattered spots with high 
      reflectivity' casting a shadow underneath. The reflectivity can be distinctly 
      differentiated from the blood vessels on the optic nerve. Two patients had an 
      arcuate scotoma on the Humphrey visual fields. No correlation was found between 
      the changes on Spectralis OCT with that of visual field. CONCLUSIONS: Spectralis 
      OCT is another useful ancillary investigation in the diagnosis of ONHD and we 
      describe the features in the present study.
FAU - Murthy, Ravi K
AU  - Murthy RK
AD  - Department of Ophthalmology, College of Medicine, University of Florida, 
      Jacksonville, Florida, USA.
FAU - Storm, Laura
AU  - Storm L
FAU - Grover, Sandeep
AU  - Grover S
FAU - Brar, Vikram S
AU  - Brar VS
FAU - Chalam, Kakarla V
AU  - Chalam KV
LA  - eng
PT  - Evaluation Study
PT  - Journal Article
DEP - 20100607
PL  - England
TA  - BMC Med Imaging
JT  - BMC medical imaging
JID - 100968553
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - *Algorithms
MH  - Female
MH  - Humans
MH  - Image Enhancement/methods
MH  - Image Interpretation, Computer-Assisted/*methods
MH  - Information Storage and Retrieval/*methods
MH  - Male
MH  - Middle Aged
MH  - Optic Disk Drusen/*pathology
MH  - Reproducibility of Results
MH  - Sensitivity and Specificity
MH  - Tomography, Optical Coherence/*methods
MH  - Young Adult
PMC - PMC2895575
EDAT- 2010/06/10 06:00
MHDA- 2010/09/25 06:00
PMCR- 2010/06/07
CRDT- 2010/06/10 06:00
PHST- 2010/01/08 00:00 [received]
PHST- 2010/06/07 00:00 [accepted]
PHST- 2010/06/10 06:00 [entrez]
PHST- 2010/06/10 06:00 [pubmed]
PHST- 2010/09/25 06:00 [medline]
PHST- 2010/06/07 00:00 [pmc-release]
AID - 1471-2342-10-11 [pii]
AID - 10.1186/1471-2342-10-11 [doi]
PST - epublish
SO  - BMC Med Imaging. 2010 Jun 7;10:11. doi: 10.1186/1471-2342-10-11.