PMID- 20530756
OWN - NLM
STAT- MEDLINE
DCOM- 20101018
LR  - 20240324
IS  - 1532-298X (Electronic)
IS  - 1040-4651 (Print)
IS  - 1040-4651 (Linking)
VI  - 22
IP  - 6
DP  - 2010 Jun
TI  - The TOR pathway modulates the structure of cell walls in Arabidopsis.
PG  - 1898-908
LID - 10.1105/tpc.109.073007 [doi]
AB  - Plant cell growth is limited by the extension of cell walls, which requires both 
      the synthesis and rearrangement of cell wall components in a controlled fashion. 
      The target of rapamycin (TOR) pathway is a major regulator of cell growth in 
      eukaryotes, and inhibition of this pathway by rapamycin reduces cell growth. 
      Here, we show that in plants, the TOR pathway affects cell wall structures. 
      LRR-extensin1 (LRX1) of Arabidopsis thaliana is an extracellular protein involved 
      in cell wall formation in root hairs, and lrx1 mutants develop aberrant root 
      hairs. rol5 (for repressor of lrx1) was identified as a suppressor of lrx1. The 
      functionally similar ROL5 homolog in yeast, Ncs6p (needs Cla4 to survive 6), was 
      previously found to affect TOR signaling. Inhibition of TOR signaling by 
      rapamycin led to suppression of the lrx1 mutant phenotype and caused specific 
      changes to galactan/rhamnogalacturonan-I and arabinogalactan protein components 
      of cell walls that were similar to those observed in the rol5 mutant. The ROL5 
      protein accumulates in mitochondria, a target of the TOR pathway and major source 
      of reactive oxygen species (ROS), and rol5 mutants show an altered response to 
      ROS. This suggests that ROL5 might function as a mitochondrial component of the 
      TOR pathway that influences the plant's response to ROS.
FAU - Leiber, Ruth-Maria
AU  - Leiber RM
AD  - University of Zurich, Institute of Plant Biology, 8008 Zurich, Switzerland.
FAU - John, Florian
AU  - John F
FAU - Verhertbruggen, Yves
AU  - Verhertbruggen Y
FAU - Diet, Anouck
AU  - Diet A
FAU - Knox, J Paul
AU  - Knox JP
FAU - Ringli, Christoph
AU  - Ringli C
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100608
PL  - England
TA  - Plant Cell
JT  - The Plant cell
JID - 9208688
RN  - 0 (Arabidopsis Proteins)
RN  - 0 (DNA, Plant)
RN  - 0 (LRX1 protein, Arabidopsis)
RN  - 0 (Reactive Oxygen Species)
RN  - 9014-25-9 (RNA, Transfer)
RN  - W36ZG6FT64 (Sirolimus)
SB  - IM
MH  - Amino Acid Sequence
MH  - Arabidopsis/*cytology/genetics/metabolism
MH  - Arabidopsis Proteins/genetics/*metabolism
MH  - Cell Wall/*metabolism
MH  - Chromosome Mapping
MH  - Cloning, Molecular
MH  - DNA, Plant/genetics
MH  - Gene Expression Regulation, Plant
MH  - Genotype
MH  - Mitochondria/metabolism
MH  - Molecular Sequence Data
MH  - Mutagenesis
MH  - Phenotype
MH  - Plant Roots/cytology
MH  - RNA, Transfer/genetics
MH  - Reactive Oxygen Species/metabolism
MH  - Saccharomyces cerevisiae/metabolism
MH  - Sequence Alignment
MH  - Signal Transduction
MH  - Sirolimus/pharmacology
PMC - PMC2910960
EDAT- 2010/06/10 06:00
MHDA- 2010/10/19 06:00
PMCR- 2011/06/01
CRDT- 2010/06/10 06:00
PHST- 2010/06/10 06:00 [entrez]
PHST- 2010/06/10 06:00 [pubmed]
PHST- 2010/10/19 06:00 [medline]
PHST- 2011/06/01 00:00 [pmc-release]
AID - tpc.109.073007 [pii]
AID - 073007 [pii]
AID - 10.1105/tpc.109.073007 [doi]
PST - ppublish
SO  - Plant Cell. 2010 Jun;22(6):1898-908. doi: 10.1105/tpc.109.073007. Epub 2010 Jun 
      8.