PMID- 20531209
OWN - NLM
STAT- MEDLINE
DCOM- 20101008
LR  - 20220318
IS  - 1944-7884 (Electronic)
IS  - 1525-4135 (Print)
IS  - 1525-4135 (Linking)
VI  - 55
IP  - 2
DP  - 2010 Oct
TI  - Biomarkers of vascular dysfunction in children infected with human 
      immunodeficiency virus-1.
PG  - 182-8
LID - 10.1097/QAI.0b013e3181e222c9 [doi]
AB  - BACKGROUND: : We compared biomarkers of vascular dysfunction among HIV-infected 
      children to a demographically similar group of uninfected children and determined 
      factors associated with these biomarkers. METHODS AND RESULTS: : We measured 
      several biomarkers of vascular dysfunction: C-reactive protein (CRP), 
      interleukin-6 (IL-6), and monocyte chemoattractant protein -1 (MCP-1) 
      (inflammation); fibrinogen and P-selectin (coagulant dysfunction); soluble 
      intracellular cell adhesion molecule-1 (sICAM), soluble vascular cell adhesion 
      molecule-1 (sVCAM), and E-selectin (endothelial dysfunction); and leptin 
      (metabolic dysfunction). Anthropometry, body composition, CD4%, HIV viral load, 
      and antiretroviral therapy were recorded. Mean age was 14.8 years (106 
      HIV-infected children) and 12.3 years (55 control children). Sex and body mass 
      index Z scores were similar. Infected children had higher sICAM, sVCAM, MCP-1, 
      IL-6, and fibrinogen levels. E-selectin (P = 0.07), and CRP (P = 0.08) trended to 
      be greater in the HIV group, yet leptin and P-selectin were similar. In 
      multivariable analyses in the HIV-infected children alone, each 1 standard 
      deviation increase in waist to hip ratio was associated with increases in sICAM 
      (17%), MCP-1 (19%), IL6 (18%), and CRP (59%). CD4% was inversely associated with 
      sVCAM, MCP-1, IL6, fibrinogen, and CRP. CONCLUSIONS: : HIV-infected children have 
      higher levels of biomarkers of vascular dysfunction than healthy children. Risk 
      factors associated with these biomarkers include higher waist to hip ratios and 
      HIV disease severity.
FAU - Miller, Tracie L
AU  - Miller TL
AD  - Division of Pediatric Clinical Research, Department of Pediatrics, Miller School 
      of Medicine, University of Miami, Miami, FL, USA.
FAU - Somarriba, Gabriel
AU  - Somarriba G
FAU - Orav, E John
AU  - Orav EJ
FAU - Mendez, Armando J
AU  - Mendez AJ
FAU - Neri, Daniela
AU  - Neri D
FAU - Schaefer, Natasha
AU  - Schaefer N
FAU - Forster, Lourdes
AU  - Forster L
FAU - Goldberg, Ronald
AU  - Goldberg R
FAU - Scott, Gwendolyn B
AU  - Scott GB
FAU - Lipshultz, Steven E
AU  - Lipshultz SE
LA  - eng
GR  - P01 DK045734/DK/NIDDK NIH HHS/United States
GR  - R01 HL095127/HL/NHLBI NIH HHS/United States
GR  - 1R01HL095127-01/HL/NHLBI NIH HHS/United States
GR  - P01DK45734/DK/NIDDK NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Acquir Immune Defic Syndr
JT  - Journal of acquired immune deficiency syndromes (1999)
JID - 100892005
RN  - 0 (Biomarkers)
RN  - 0 (CCL2 protein, human)
RN  - 0 (Chemokine CCL2)
RN  - 0 (E-Selectin)
RN  - 0 (Leptin)
RN  - 0 (P-Selectin)
RN  - 0 (Vascular Cell Adhesion Molecule-1)
RN  - 9001-32-5 (Fibrinogen)
RN  - 9007-41-4 (C-Reactive Protein)
SB  - IM
CIN - Biomark Med. 2010 Oct;4(5):751. PMID: 20945989
MH  - Adolescent
MH  - Biomarkers/*blood
MH  - Blood Vessels/*physiopathology
MH  - C-Reactive Protein/analysis
MH  - Case-Control Studies
MH  - Chemokine CCL2/blood
MH  - Child
MH  - E-Selectin/blood
MH  - Female
MH  - Fibrinogen/analysis
MH  - HIV Infections/*blood/physiopathology
MH  - *HIV-1
MH  - Humans
MH  - Leptin/blood
MH  - Male
MH  - Multivariate Analysis
MH  - P-Selectin/blood
MH  - Vascular Cell Adhesion Molecule-1/blood
MH  - Waist-Hip Ratio
PMC - PMC2943965
MID - NIHMS213400
COIS- DISCLOSURES The authors have no potential, perceived, or real conflicts of 
      interest.
EDAT- 2010/06/10 06:00
MHDA- 2010/10/12 06:00
PMCR- 2011/10/01
CRDT- 2010/06/10 06:00
PHST- 2010/06/10 06:00 [entrez]
PHST- 2010/06/10 06:00 [pubmed]
PHST- 2010/10/12 06:00 [medline]
PHST- 2011/10/01 00:00 [pmc-release]
AID - 10.1097/QAI.0b013e3181e222c9 [doi]
PST - ppublish
SO  - J Acquir Immune Defic Syndr. 2010 Oct;55(2):182-8. doi: 
      10.1097/QAI.0b013e3181e222c9.