PMID- 20534459
OWN - NLM
STAT- MEDLINE
DCOM- 20100714
LR  - 20211020
IS  - 1091-6490 (Electronic)
IS  - 0027-8424 (Print)
IS  - 0027-8424 (Linking)
VI  - 107
IP  - 24
DP  - 2010 Jun 15
TI  - Neural correlates of anchoring-and-adjustment during mentalizing.
PG  - 10827-32
LID - 10.1073/pnas.1003242107 [doi]
AB  - Recent studies have suggested that the medial prefrontal cortex (MPFC) 
      contributes both to understanding the mental states of others and to 
      introspecting about one's own mind. This finding has suggested that perceivers 
      might use their own thoughts and feelings as a starting point for making 
      inferences about others, consistent with "simulation" or "self-projection" views 
      of social cognition. However, perceivers cannot simply assume that others think 
      and feel exactly as they do; social cognition also must include processes that 
      adjust for perceived differences between self and other. Recent cognitive work 
      has suggested that such correction occurs through a process of 
      "anchoring-and-adjustment" by which perceivers serially tune their inferences 
      from an initial starting point based on their own introspections. Here, we used 
      functional MRI to test two predictions derived from this anchoring-and-adjustment 
      view. Participants (n = 64) used a Likert scale to judge the preferences of 
      another person and to indicate their own preferences on the same items, allowing 
      us to calculate the discrepancy between the participant's answers for self and 
      other. Whole-brain parametric analyses identified a region in the MPFC in which 
      activity was related linearly to this self-other discrepancy when inferring the 
      mental states of others. These findings suggest both that the self serves as an 
      important starting point from which to understand others and that perceivers 
      customize such inferences by serially adjusting away from this anchor.
FAU - Tamir, Diana I
AU  - Tamir DI
AD  - Department of Psychology, Harvard University, Cambridge, MA 02138, USA. 
      dtamir@fas.harvard.edu
FAU - Mitchell, Jason P
AU  - Mitchell JP
LA  - eng
GR  - P41 RR014075/RR/NCRR NIH HHS/United States
GR  - P41 RR14075/RR/NCRR NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, U.S. Gov't, Non-P.H.S.
DEP - 20100601
PL  - United States
TA  - Proc Natl Acad Sci U S A
JT  - Proceedings of the National Academy of Sciences of the United States of America
JID - 7505876
RN  - S88TT14065 (Oxygen)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Comprehension/physiology
MH  - Female
MH  - Humans
MH  - Interpersonal Relations
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - *Models, Neurological
MH  - Oxygen/blood
MH  - Prefrontal Cortex/blood supply/physiology
MH  - Self Concept
MH  - Social Adjustment
MH  - Social Behavior
MH  - Social Perception
MH  - Theory of Mind/*physiology
MH  - Young Adult
PMC - PMC2890763
COIS- The authors declare no conflict of interest.
EDAT- 2010/06/11 06:00
MHDA- 2010/07/16 06:00
PMCR- 2010/12/15
CRDT- 2010/06/11 06:00
PHST- 2010/06/11 06:00 [entrez]
PHST- 2010/06/11 06:00 [pubmed]
PHST- 2010/07/16 06:00 [medline]
PHST- 2010/12/15 00:00 [pmc-release]
AID - 1003242107 [pii]
AID - 201003242 [pii]
AID - 10.1073/pnas.1003242107 [doi]
PST - ppublish
SO  - Proc Natl Acad Sci U S A. 2010 Jun 15;107(24):10827-32. doi: 
      10.1073/pnas.1003242107. Epub 2010 Jun 1.