PMID- 20534842
OWN - NLM
STAT- MEDLINE
DCOM- 20100824
LR  - 20211020
IS  - 1529-2401 (Electronic)
IS  - 0270-6474 (Print)
IS  - 0270-6474 (Linking)
VI  - 30
IP  - 23
DP  - 2010 Jun 9
TI  - A calorie-restricted diet decreases brain iron accumulation and preserves motor 
      performance in old rhesus monkeys.
PG  - 7940-7
LID - 10.1523/JNEUROSCI.0835-10.2010 [doi]
AB  - Caloric restriction (CR) reduces the pathological effects of aging and extends 
      the lifespan in many species, including nonhuman primates, although the effect on 
      the brain is less well characterized. We used two common indicators of aging, 
      motor performance speed and brain iron deposition measured in vivo using MRI, to 
      determine the potential effect of CR on elderly rhesus macaques eating restricted 
      (n = 24; 13 males, 11 females) and standard diets (n = 17; 8 males, 9 females). 
      Both the CR and control monkeys showed age-related increases in iron 
      concentrations in globus pallidus (GP) and substantia nigra (SN), although the CR 
      group had significantly less iron deposition in the GP, SN, red nucleus, and 
      temporal cortex. A diet x age interaction revealed that CR modified age-related 
      brain changes, evidenced as attenuation in the rate of iron accumulation in basal 
      ganglia and parietal, temporal, and perirhinal cortex. Additionally, control 
      monkeys had significantly slower fine motor performance on the Movement 
      Assessment Panel, which was negatively correlated with iron accumulation in left 
      SN and parietal lobe, although CR animals did not show this relationship. Our 
      observations suggest that the CR-induced benefit of reduced iron deposition and 
      preserved motor function may indicate neural protection similar to effects 
      described previously in aging rodent and primate species.
FAU - Kastman, Erik K
AU  - Kastman EK
AD  - Geriatric Research Education and Clinical Center, William S. Middleton Memorial 
      Veterans Hospital, Madison, Wisconsin 53705, USA.
FAU - Willette, Auriel A
AU  - Willette AA
FAU - Coe, Christopher L
AU  - Coe CL
FAU - Bendlin, Barbara B
AU  - Bendlin BB
FAU - Kosmatka, Kris J
AU  - Kosmatka KJ
FAU - McLaren, Donald G
AU  - McLaren DG
FAU - Xu, Guofan
AU  - Xu G
FAU - Canu, Elisa
AU  - Canu E
FAU - Field, Aaron S
AU  - Field AS
FAU - Alexander, Andrew L
AU  - Alexander AL
FAU - Voytko, Mary Lou
AU  - Voytko ML
FAU - Beasley, T Mark
AU  - Beasley TM
FAU - Colman, Ricki J
AU  - Colman RJ
FAU - Weindruch, Richard H
AU  - Weindruch RH
FAU - Johnson, Sterling C
AU  - Johnson SC
LA  - eng
GR  - R01 AG043125/AG/NIA NIH HHS/United States
GR  - P01 AG11915/AG/NIA NIH HHS/United States
GR  - AG000213/AG/NIA NIH HHS/United States
GR  - T32 AG000213/AG/NIA NIH HHS/United States
GR  - P01 AG011915-140005/AG/NIA NIH HHS/United States
GR  - P01 AG011915/AG/NIA NIH HHS/United States
GR  - P01 AG011915-120005/AG/NIA NIH HHS/United States
GR  - P01 AG011915-150005/AG/NIA NIH HHS/United States
GR  - P51 OD011106/OD/NIH HHS/United States
GR  - P01 AG011915-130005/AG/NIA NIH HHS/United States
GR  - P01 AG011915-11A20005/AG/NIA NIH HHS/United States
GR  - C06 RR020141/RR/NCRR NIH HHS/United States
GR  - C06 RR015459/RR/NCRR NIH HHS/United States
GR  - P51 RR000167/RR/NCRR NIH HHS/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PL  - United States
TA  - J Neurosci
JT  - The Journal of neuroscience : the official journal of the Society for 
      Neuroscience
JID - 8102140
RN  - E1UOL152H7 (Iron)
SB  - IM
EIN - J Neurosci. 2012 Aug 22;32(34):11904
CRI - J Neurosci. 2012 Aug 22;32(34):11897-904. PMID: 23082321
MH  - Aging/*metabolism
MH  - Animals
MH  - Basal Ganglia/metabolism
MH  - Brain/*metabolism
MH  - *Caloric Restriction/methods
MH  - Female
MH  - Globus Pallidus/metabolism
MH  - Iron/*metabolism
MH  - Macaca mulatta
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - *Motor Activity
MH  - *Movement
MH  - Parietal Lobe/metabolism
MH  - Red Nucleus/metabolism
MH  - Substantia Nigra/metabolism
MH  - Temporal Lobe/metabolism
PMC - PMC2898557
MID - NIHMS212067
EDAT- 2010/06/11 06:00
MHDA- 2010/08/25 06:00
PMCR- 2010/12/09
CRDT- 2010/06/11 06:00
PHST- 2010/06/11 06:00 [entrez]
PHST- 2010/06/11 06:00 [pubmed]
PHST- 2010/08/25 06:00 [medline]
PHST- 2010/12/09 00:00 [pmc-release]
AID - 30/23/7940 [pii]
AID - 3605539 [pii]
AID - 10.1523/JNEUROSCI.0835-10.2010 [doi]
PST - ppublish
SO  - J Neurosci. 2010 Jun 9;30(23):7940-7. doi: 10.1523/JNEUROSCI.0835-10.2010.