PMID- 20535140
OWN - NLM
STAT- MEDLINE
DCOM- 20110617
LR  - 20141120
IS  - 1476-5527 (Electronic)
IS  - 0950-9240 (Linking)
VI  - 25
IP  - 3
DP  - 2011 Mar
TI  - Antihypertensive and renoprotective effects of trandolapril/verapamil 
      combination: a meta-analysis of randomized controlled trials.
PG  - 203-10
LID - 10.1038/jhh.2010.60 [doi]
AB  - Both trandolapril and verapamil are effective and widely used antihypertensive 
      agents. The aim of this study was to estimate the efficacy and tolerability of 
      trandolapril/verapamil (Tr/Ve) combination for blood pressure control and 
      renoprotection. PubMed, EMBASE and Cochrane Library were searched for relevant 
      studies. A meta-analysis of all randomized controlled trials (RCTs) meeting the 
      criteria was performed. Twelve RCTs were ultimately included out of 62 studies. 
      (1) Combination versus trandolapril: a greater diastolic blood pressure (DBP) 
      reduction (weighted mean difference (WMD): 3.71, 95% confidence interval (CI): 
      1.84-5.57); a greater reduction in albuminuria (WMD: 136.77, 95% CI: 
      12.44-261.09). There were no differences in reduction in systolic blood pressure 
      (SBP), blood pressure response rate or proteinuria. (2) Combination versus 
      verapamil: a greater SBP reduction (WMD: 6.14, 95% CI: 3.59-8.70); a greater DBP 
      reduction (WMD: 2.49, 95% CI: 0.81-4.17); a greater reduction in proteinuria 
      (standardized mean difference: 0.84, 95% CI: 0.22-1.45); a greater reduction in 
      albuminuria (WMD: 255.00, 95% CI: 119.26-390.74). (3) Incidence of all-cause 
      adverse events (AEs) was comparable between combination and monotherapy. The 
      present meta-analysis indicates that Tr/Ve combination provides a superior blood 
      pressure control and a favourable renoprotective effect without an increase of 
      overall AEs than verapamil monotherapy. The combination also shows a slight 
      advantage over trandolapril monotherapy by reducing DBP and albuminuria to a 
      greater extent.
FAU - Zou, Z
AU  - Zou Z
AD  - Department of Anesthesiology, Changzheng Hospital, Second Military Medical 
      University, Shanghai, PR China.
FAU - Xu, F-Y
AU  - Xu FY
FAU - Wang, L
AU  - Wang L
FAU - An, M-M
AU  - An MM
FAU - Zhang, H
AU  - Zhang H
FAU - Shi, X-Y
AU  - Shi XY
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
DEP - 20100610
PL  - England
TA  - J Hum Hypertens
JT  - Journal of human hypertension
JID - 8811625
RN  - 0 (Antihypertensive Agents)
RN  - 0 (Indoles)
RN  - 1T0N3G9CRC (trandolapril)
RN  - CJ0O37KU29 (Verapamil)
SB  - IM
MH  - Albuminuria/drug therapy
MH  - Antihypertensive Agents/adverse effects/*therapeutic use
MH  - Drug Therapy, Combination/adverse effects
MH  - Female
MH  - Humans
MH  - Hypertension/complications/*drug therapy
MH  - Indoles/adverse effects/*therapeutic use
MH  - Kidney/*drug effects
MH  - Kidney Diseases/etiology/*prevention & control
MH  - Male
MH  - Middle Aged
MH  - Randomized Controlled Trials as Topic
MH  - Treatment Outcome
MH  - Verapamil/adverse effects/*therapeutic use
EDAT- 2010/06/11 06:00
MHDA- 2011/06/18 06:00
CRDT- 2010/06/11 06:00
PHST- 2010/06/11 06:00 [entrez]
PHST- 2010/06/11 06:00 [pubmed]
PHST- 2011/06/18 06:00 [medline]
AID - jhh201060 [pii]
AID - 10.1038/jhh.2010.60 [doi]
PST - ppublish
SO  - J Hum Hypertens. 2011 Mar;25(3):203-10. doi: 10.1038/jhh.2010.60. Epub 2010 Jun 
      10.