PMID- 2053526
OWN - NLM
STAT- MEDLINE
DCOM- 19910724
LR  - 20151008
IS  - 0029-0203 (Print)
IS  - 0029-0203 (Linking)
VI  - 95
IP  - 2
DP  - 1991 Feb
TI  - [Cyanide with vitamin B12 deficiency as the cause of experimental tobacco 
      amblyopia].
PG  - 158-64
AB  - The visual toxicity of tobacco smoke was studied and demyelination change of 
      retrobulbar portion of the rat's optic nerve with an elongation of a peak latency 
      time of visual evoked potentials (VEP) was demonstrated. Cyanide detoxication 
      incapacity and deficiency of vitamin B12 (B12) have been considered as possible 
      causes of tobacco amblyopia. In order to elucidate an influence of cyanide 
      poisoning and B12 deficiency on the visual system, 12 male Wistar rats were 
      subjected to 5 hour's daily inhalation of cyanide gas for 52 weeks, the 
      concentration of which was adjusted to that of tobacco smoke. Six rats of these 
      12 were fed with a lacking B12 diet. Another 12 male Wistar rats were controls 
      which did not undergo inhalation of cyanide gas, and half of them were fed a diet 
      without B12. In 2 out of 6 rats with cyanide and inhalation and B12 deficiency, 
      demyelination change could be recognized in the central portion of the 
      retrobulbar optic nerve. The histological change was segmental and significant 
      elongation of the peak latency time of VEP was not recognized. Cyanide gas 
      inhalation at a low concentration was proved to be harmful to the optic nerve 
      under the condition of B12 deficiency, but other toxic elements such as nicotine 
      and carbon monoxide may be important factors to cause the more severe changes of 
      the optic nerve with an abnormal VEP response recognized in the experimental 
      tobacco amblyopia.
FAU - Oku, H
AU  - Oku H
AD  - Department of Ophthalmology, Osaka Medical College, Takatsuki, Japan.
FAU - Fukushima, K
AU  - Fukushima K
FAU - Miyata, M
AU  - Miyata M
FAU - Wakakura, M
AU  - Wakakura M
FAU - Ishikawa, S
AU  - Ishikawa S
LA  - jpn
PT  - English Abstract
PT  - Journal Article
PL  - Japan
TA  - Nippon Ganka Gakkai Zasshi
JT  - Nippon Ganka Gakkai zasshi
JID - 7505716
RN  - 0 (Cyanides)
RN  - 0 (Tobacco Smoke Pollution)
SB  - IM
MH  - Amblyopia/*etiology/pathology
MH  - Animals
MH  - Cyanides/*toxicity
MH  - Male
MH  - Optic Nerve/pathology
MH  - Rats
MH  - Rats, Inbred Strains
MH  - Tobacco Smoke Pollution/adverse effects
MH  - Vitamin B 12 Deficiency/complications
EDAT- 1991/02/01 00:00
MHDA- 1991/02/01 00:01
CRDT- 1991/02/01 00:00
PHST- 1991/02/01 00:00 [pubmed]
PHST- 1991/02/01 00:01 [medline]
PHST- 1991/02/01 00:00 [entrez]
PST - ppublish
SO  - Nippon Ganka Gakkai Zasshi. 1991 Feb;95(2):158-64.