PMID- 20536280
OWN - NLM
STAT- MEDLINE
DCOM- 20100714
LR  - 20151119
IS  - 1532-4303 (Electronic)
IS  - 0277-0903 (Linking)
VI  - 47
IP  - 5
DP  - 2010 Jun
TI  - Genetic polymorphism of manganese superoxide dismutase is associated with 
      childhood asthma.
PG  - 532-8
LID - 10.3109/02770901003686472 [doi]
AB  - OBJECTIVE: Cellular defenses against allergens and reactive oxygen species (ROS) 
      exposure are critical in the pathogenesis of asthma. CD14 is a receptor for 
      various bacterial products, such as lipopolysaccharides (LPS), and is also a 
      mediator of inflammatory processes. Manganese superoxide dismutase (MnSOD) is an 
      ROS scavenger, and myeloperoxidase (MPO) can convert hydrogen peroxide into 
      hypochlorous acid; thus, they are considered to be involved in inflammatory 
      defense. The authors conducted a case-control study to evaluate the 
      susceptibility to childhood asthma based on CD14, MnSOD, and MPO genes. METHODS: 
      The CD14 -260, MnSOD -9, and MPO -463 genotypes were identified by polymerase 
      chain reactions for 116 asthmatic children and 232 healthy controls. 
      Questionnaires were administered to obtain demographic characteristics. Allergen 
      testing used common Taiwanese aeroallergens. RESULTS: A higher level of parental 
      education, family history of asthma, incense burning at home, allergen-test 
      positive, and the MnSOD Val-Ala/Ala-Ala genotypes (matched relative risk = 2.0; 
      95% confidence interval = 1.0-4.2) were significantly associated with childhood 
      asthma. Interactions between CD14, MnSOD, MPO genotypes and allergy status were 
      significantly associated with asthma risk in these children (all p <.001). 
      Furthermore, atopic cases with MnSOD Val-Ala/Ala-Ala (log eosinophil 2.66/mm(3), 
      log total serum immunoglobulin E [IgE] 2.48 IU/ml) or Val-Val (log eosinophil 
      2.61/mm(3), log total serum IgE 2.63 IU/ml) genotypes had elevated eosinophil 
      counts and total serum IgE levels as compared to nonatopic cases with MnSOD 
      Val-Val genotype (log eosinophil 2.27/mm(3), log total serum IgE 1.83 IU/ml). 
      CONCLUSIONS: Susceptible MnSOD genotypes might modulate the development of asthma 
      in Taiwanese children.
FAU - Kuo Chou, Tsai-Nung
AU  - Kuo Chou TN
AD  - Institute of Medicine, College of Health Care and Management, Chung-Shan Medical 
      University Hospital, Taichung, Taiwan.
FAU - Li, Ying-Shiuan
AU  - Li YS
FAU - Lue, Ko-Huang
AU  - Lue KH
FAU - Liao, Che-Feng
AU  - Liao CF
FAU - Lin, Chien-Yu
AU  - Lin CY
FAU - Tzeng, Pei-Rung
AU  - Tzeng PR
FAU - Wong, Ruey-Hong
AU  - Wong RH
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - J Asthma
JT  - The Journal of asthma : official journal of the Association for the Care of 
      Asthma
JID - 8106454
RN  - 0 (Reactive Oxygen Species)
RN  - EC 1.15.1.1 (Superoxide Dismutase)
SB  - IM
MH  - Age Factors
MH  - Asthma/diagnosis/*epidemiology/*genetics
MH  - Bronchial Hyperreactivity/diagnosis/epidemiology/*genetics
MH  - Case-Control Studies
MH  - Child
MH  - Child, Preschool
MH  - Confidence Intervals
MH  - Female
MH  - Follow-Up Studies
MH  - Genetic Predisposition to Disease/*epidemiology
MH  - Genotype
MH  - Humans
MH  - Incidence
MH  - Male
MH  - Polymorphism, Genetic
MH  - Probability
MH  - Reactive Oxygen Species/metabolism
MH  - Reference Values
MH  - Risk Assessment
MH  - Sex Factors
MH  - Superoxide Dismutase/*genetics
MH  - Surveys and Questionnaires
MH  - Taiwan/epidemiology
EDAT- 2010/06/12 06:00
MHDA- 2010/07/16 06:00
CRDT- 2010/06/12 06:00
PHST- 2010/06/12 06:00 [entrez]
PHST- 2010/06/12 06:00 [pubmed]
PHST- 2010/07/16 06:00 [medline]
AID - 10.3109/02770901003686472 [doi]
PST - ppublish
SO  - J Asthma. 2010 Jun;47(5):532-8. doi: 10.3109/02770901003686472.