PMID- 20536513
OWN - NLM
STAT- MEDLINE
DCOM- 20101018
LR  - 20100611
IS  - 1464-5491 (Electronic)
IS  - 0742-3071 (Linking)
VI  - 27
IP  - 4
DP  - 2010 Apr
TI  - Do high ferritin levels confer lower cardiovascular risk in men with Type 2 
      diabetes?
PG  - 417-22
LID - 10.1111/j.1464-5491.2010.02979.x [doi]
AB  - AIMS: High ferritin levels are associated with insulin resistance and liver 
      steatosis, both thought of as emerging cardiovascular risk factors. The 
      association between ferritin and cardiovascular disease is poorly documented in 
      cardiometabolic states with higher cardiovascular risk, such as diabetes and 
      metabolic syndrome. We therefore characterized a cohort of males with Type 2 
      diabetes mellitus (T2DM) according to ferritin levels and prevalent 
      macroangiopathy. METHODS: The presence of overall macroangiopathy, peripheral 
      and/or coronary artery disease was documented in 424 consecutive T2DM males, who 
      were divided according to ferritin quartiles (Q) as follows: QI-III, normal 
      ferritin (NF; n=318), mean+/-1 sd ferritin 133+/-72 ng/ml; and QIV patients, high 
      ferritin (HF; n=106), ferritin 480+/-228 ng/ml. RESULTS: Age, age at diabetes 
      diagnosis, smoking, ethanol intake, body mass index, waist circumference, blood 
      pressure and presence of metabolic syndrome did not differ between groups. 
      However, the prevalence of macroangiopathy was unexpectedly much lower in 
      patients with high ferritin, as follows: 25% vs. 43% for overall macroangiopathy; 
      7% vs. 16% for peripheral artery disease; and 16% vs. 31% for coronary artery 
      disease (P=0.0009, P=0.0140 and P=0.0035, respectively, vs. NF patients). Insulin 
      resistance index and prevalence of liver steatosis were higher in HF compared 
      with NF patients as follows: 2.17% vs. 1.89% and 78% vs. 64% (P=0.0345 and 
      P=0.0059, respectively). Liver enzymes (aspartate aminotransferase, alanine 
      aminotransferase and gamma-glutamyl transferase) were significantly higher in HF, 
      by 33%, 42% and 72%, respectively (all P<0.0002), suggesting a higher prevalence 
      of steatohepatitis. Glycated haemoglobin, low-density lipoprotein-cholesterol, 
      high-density lipoprotein-cholesterol, triglycerides, urate, high-sensitivity 
      C-reactive protein and albuminuria were not different between groups. 
      CONCLUSIONS: Our results demonstrate that T2DM males with high ferritin levels 
      exhibit a markedly decreased prevalence of macroangiopathy, despite more severe 
      insulin resistance and higher markers of steatohepatitis. High ferritin levels 
      and/or steatosis may thus paradoxically confer a lowered cardiovascular risk in 
      diabetic males.
FAU - Hermans, M P
AU  - Hermans MP
AD  - Endocrinology Department, Cliniques universitaires St-Luc, Universite catholique 
      de Louvain, Brussels, Belgium. michel.hermans@diab.ucl.ac.be
FAU - Ahn, S A
AU  - Ahn SA
FAU - Amoussou-Guenou, K D
AU  - Amoussou-Guenou KD
FAU - Balde, N M
AU  - Balde NM
FAU - Rousseau, M F
AU  - Rousseau MF
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Diabet Med
JT  - Diabetic medicine : a journal of the British Diabetic Association
JID - 8500858
RN  - 9007-73-2 (Ferritins)
SB  - IM
MH  - Cohort Studies
MH  - Coronary Disease/*epidemiology
MH  - Cross-Sectional Studies
MH  - Diabetes Mellitus, Type 2/*blood
MH  - Fatty Liver/epidemiology
MH  - Ferritins/*blood
MH  - Humans
MH  - Insulin Resistance/physiology
MH  - Male
MH  - Middle Aged
MH  - Prevalence
MH  - Risk
MH  - Stroke/*epidemiology
EDAT- 2010/06/12 06:00
MHDA- 2010/10/19 06:00
CRDT- 2010/06/12 06:00
PHST- 2010/06/12 06:00 [entrez]
PHST- 2010/06/12 06:00 [pubmed]
PHST- 2010/10/19 06:00 [medline]
AID - DME2979 [pii]
AID - 10.1111/j.1464-5491.2010.02979.x [doi]
PST - ppublish
SO  - Diabet Med. 2010 Apr;27(4):417-22. doi: 10.1111/j.1464-5491.2010.02979.x.