PMID- 20536911
OWN - NLM
STAT- MEDLINE
DCOM- 20110218
LR  - 20221207
IS  - 1432-2277 (Electronic)
IS  - 0934-0874 (Linking)
VI  - 23
IP  - 12
DP  - 2010 Dec
TI  - Impact of amino acid substitution at residue 9 of HLA-A2 on the development of 
      acute GVHD in Korean pediatric patients receiving unrelated hematopoietic stem 
      cell transplantation.
PG  - 1216-22
LID - 10.1111/j.1432-2277.2010.01117.x [doi]
AB  - Incompatibility of human leukocyte antigen (HLA) alleles between donors and 
      recipients of unrelated hematopoietic stem cell transplantation (UHSCT) increases 
      the risk of acute graft-versus-host disease (GVHD). We evaluated the positional 
      effect of amino acid substitutions in HLA molecules on severe acute GVHD in 
      Korean pediatric recipients of UHSCT. All of 64 donor-recipient pairs were 
      serologically matched for HLA-A, -B, and -DR loci. Only substitution at residue 9 
      resulting from an HLA-A*02 polymorphism was significantly associated with the 
      risk of severe acute GVHD in patients (OR=7.0, P=0.033) on multivariate analysis. 
      Recipients of this mismatched HLA also showed shortened overall survival (HR=9.7, 
      P<0.001) and increased risk for transplant-related mortality (HR=9.1, P=0.027). 
      Structural modeling showed that the amino acid substitution could alter the 
      peptide preference of the ligand-binding pocket. A single amino acid substitution 
      at position 9 was a major predictor of severe acute GVHD in Korean pediatric 
      patients.
CI  - (c) 2010 The Authors. Journal compilation (c) 2010 European Society for Organ 
      Transplantation.
FAU - Hwang, Sang-Hyun
AU  - Hwang SH
AD  - Department of Laboratory Medicine, Pusan National University School of Medicine, 
      Busan, Korea.
FAU - Oh, Heung-Bum
AU  - Oh HB
FAU - Choi, Sung-Eun
AU  - Choi SE
FAU - Seo, Jong-Jin
AU  - Seo JJ
FAU - Lee, Jae-Hwan
AU  - Lee JH
FAU - Cho, Sung-Woo
AU  - Cho SW
FAU - Chae, Jeong-Min
AU  - Chae JM
FAU - Heo, Yong-Seok
AU  - Heo YS
FAU - Chang, Chulhun L
AU  - Chang CL
FAU - Lee, Eun-Yup
AU  - Lee EY
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Switzerland
TA  - Transpl Int
JT  - Transplant international : official journal of the European Society for Organ 
      Transplantation
JID - 8908516
RN  - 0 (HLA-A2 Antigen)
SB  - IM
MH  - Adolescent
MH  - Amino Acid Sequence
MH  - Amino Acid Substitution
MH  - Asian People/genetics
MH  - Child
MH  - Child, Preschool
MH  - Female
MH  - Graft vs Host Disease/*genetics
MH  - HLA-A2 Antigen/*genetics/immunology
MH  - Hematopoietic Stem Cell Transplantation/*adverse effects/mortality
MH  - Histocompatibility Testing
MH  - Humans
MH  - Infant
MH  - Infant, Newborn
MH  - Leukemia, Myeloid, Acute/therapy
MH  - Logistic Models
MH  - Male
MH  - Models, Molecular
MH  - Precursor Cell Lymphoblastic Leukemia-Lymphoma/therapy
MH  - Republic of Korea
EDAT- 2010/06/12 06:00
MHDA- 2011/02/22 06:00
CRDT- 2010/06/12 06:00
PHST- 2010/06/12 06:00 [entrez]
PHST- 2010/06/12 06:00 [pubmed]
PHST- 2011/02/22 06:00 [medline]
AID - TRI1117 [pii]
AID - 10.1111/j.1432-2277.2010.01117.x [doi]
PST - ppublish
SO  - Transpl Int. 2010 Dec;23(12):1216-22. doi: 10.1111/j.1432-2277.2010.01117.x.