PMID- 20537392
OWN - NLM
STAT- MEDLINE
DCOM- 20100921
LR  - 20220409
IS  - 1873-6750 (Electronic)
IS  - 0160-4120 (Linking)
VI  - 36
IP  - 7
DP  - 2010 Oct
TI  - Human exposure to persistent organic pollutants in West Africa--a temporal trend 
      study from Guinea-Bissau.
PG  - 675-82
LID - 10.1016/j.envint.2010.04.020 [doi]
AB  - BACKGROUND: Humans, independent on where they live, are exposed to complex and 
      various mixtures of chemicals, including persistent organic pollutants (POPs). 
      The variability of the exposure depends on sources of the chemicals and is 
      influenced by e.g. geography, social and cultural heritage. While exposures to 
      POPs are frequently studied in populations from developed industrial countries, 
      very little is known on levels and trends of POPs in developing countries, 
      especially in Africa. OBJECTIVES: The aim of the present study was to investigate 
      levels and temporal trends of POPs in adults from Guinea-Bissau. METHODS: Serum 
      samples were obtained from an open cohort of police officers in Guinea-Bissau. 
      Repeated samples from 33 individuals were obtained at five time points between 
      1990 and 2007, in all 147 samples. Pooled serum samples were extracted and 
      cleaned-up prior to analysis by gas chromatography and mass spectrometry. The 
      concentration of 1,1,1-trichloro-2,2-bis(4-chlorophenyl)ethane (4,4'-DDT) and its 
      metabolites, polychlorinated biphenyls (PCBs), polybrominated diphenyl ethers 
      (PBDEs) and hexachlorocyclohexanes (HCHs) were determined. RESULTS: The major POP 
      found in all samples was 1,1-dichloro-2,2-bis(4-chlorophenyl)ethene (4,4'-DDE) 
      followed by 4,4'-DDT. 4,4'-DDE, 4,4'-DDT, PCBs and beta- and gamma-HCH were 
      significantly decreasing over time. The PBDEs were found at low concentrations, 
      with an increasing temporal trend for BDE-153. CONCLUSION: National and 
      international management may be behind the observed decreased organohalogen 
      compound concentrations in humans from Guinea-Bissau from the early 1990's and 
      onwards, similarly to the development of these compounds in humans from 
      industrial countries. In contrast, PBDEs follow a trend of increasing 
      concentrations even though at low levels.
CI  - Copyright 2010 Elsevier Ltd. All rights reserved.
FAU - Linderholm, Linda
AU  - Linderholm L
AD  - Environmental Chemistry Unit, Department of Materials and Environmental 
      Chemistry, Stockholm University, SE-106 91 Stockholm, Sweden. 
      linda.linderholm@mmk.su.se
FAU - Biague, Antonio
AU  - Biague A
FAU - Mansson, Fredrik
AU  - Mansson F
FAU - Norrgren, Hans
AU  - Norrgren H
FAU - Bergman, Ake
AU  - Bergman A
FAU - Jakobsson, Kristina
AU  - Jakobsson K
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - Environ Int
JT  - Environment international
JID - 7807270
RN  - 0 (Environmental Pollutants)
RN  - 0 (Halogenated Diphenyl Ethers)
RN  - 0 (Organic Chemicals)
RN  - 4M7FS82U08 (Dichlorodiphenyl Dichloroethylene)
RN  - 59NEE7PCAB (Hexachlorocyclohexane)
RN  - CIW5S16655 (DDT)
RN  - DFC2HB4I0K (Polychlorinated Biphenyls)
RN  - V14159DF29 (Dichlorodiphenyldichloroethane)
SB  - IM
MH  - Adult
MH  - DDT/blood
MH  - Dichlorodiphenyl Dichloroethylene/blood
MH  - Dichlorodiphenyldichloroethane/blood
MH  - Environmental Exposure/*analysis/statistics & numerical data
MH  - *Environmental Monitoring
MH  - Environmental Pollutants/*blood
MH  - Female
MH  - Guinea-Bissau
MH  - Halogenated Diphenyl Ethers/blood
MH  - Hexachlorocyclohexane/blood
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Organic Chemicals/*blood
MH  - Polychlorinated Biphenyls/blood
MH  - Time
MH  - Young Adult
EDAT- 2010/06/12 06:00
MHDA- 2010/09/23 06:00
CRDT- 2010/06/12 06:00
PHST- 2009/11/17 00:00 [received]
PHST- 2010/04/29 00:00 [revised]
PHST- 2010/04/30 00:00 [accepted]
PHST- 2010/06/12 06:00 [entrez]
PHST- 2010/06/12 06:00 [pubmed]
PHST- 2010/09/23 06:00 [medline]
AID - S0160-4120(10)00086-3 [pii]
AID - 10.1016/j.envint.2010.04.020 [doi]
PST - ppublish
SO  - Environ Int. 2010 Oct;36(7):675-82. doi: 10.1016/j.envint.2010.04.020.