PMID- 20538027
OWN - NLM
STAT- MEDLINE
DCOM- 20110131
LR  - 20211020
IS  - 1879-1166 (Electronic)
IS  - 0198-8859 (Linking)
VI  - 71
IP  - 9
DP  - 2010 Sep
TI  - HLA class I amino acid sequence-based matching after interlocus subtraction and 
      long-term outcome after deceased donor kidney transplantation.
PG  - 851-6
LID - 10.1016/j.humimm.2010.06.003 [doi]
AB  - We have shown previously that human leukocyte antigen (HLA) immunogenicity, 
      defined by the physiochemical properties of mismatched amino acids, predicts 
      humoral alloimmunity, and now report the effect on long-term graft survival after 
      kidney transplantation. The influence of HLA-A and -B mismatch, number of amino 
      acid mismatches (after interlocus subtraction) and their physiochemical 
      (electrostatic and hydrophobic) disparity on the outcome of fully HLA matched and 
      single HLA-A or -B mismatched deceased donor kidney transplants undertaken in the 
      United Kingdom (1990-2005) were analyzed (n = 5,247). Grafts with a single HLA-A 
      or -B mismatch had significantly lower survival than fully matched transplants 
      (81.9% vs 84.2% at 5 years, p = 0.004). However, single HLA-A or -B mismatched 
      grafts with no or one amino acid mismatch had better survival than grafts with 
      two or more amino acid mismatches (89.3% vs 81.8% at 5 years, HR 1.5, p = 0.03). 
      The number of mismatched amino acids was an independent predictor of transplant 
      survival after adjusting for the underlying HLA matching effect (p = 0.02). 
      Physiochemical disparity scores correlated closely with amino acid mismatches and 
      provided no additional predictive value. The immunogenicity of HLA class I 
      alloantigens defined at the level of amino acid sequence correlates more closely 
      with outcome after renal transplantation than conventional serologic HLA 
      matching.
CI  - Copyright 2010 American Society for Histocompatibility and Immunogenetics. 
      Published by Elsevier Inc. All rights reserved.
FAU - Kosmoliaptsis, Vasilis
AU  - Kosmoliaptsis V
AD  - Tissue Typing Laboratory, Cambridge University Hospitals NHS Foundation Trust, 
      Addenbrooke's Hospital, Cambridge, England.
FAU - Sharples, Linda D
AU  - Sharples LD
FAU - Chaudhry, Afzal
AU  - Chaudhry A
FAU - Johnson, Rachel J
AU  - Johnson RJ
FAU - Fuggle, Susan V
AU  - Fuggle SV
FAU - Halsall, David J
AU  - Halsall DJ
FAU - Bradley, J Andrew
AU  - Bradley JA
FAU - Taylor, Craig J
AU  - Taylor CJ
LA  - eng
GR  - MC_U105232027/MRC_/Medical Research Council/United Kingdom
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20100609
PL  - United States
TA  - Hum Immunol
JT  - Human immunology
JID - 8010936
RN  - 0 (Amino Acids)
RN  - 0 (HLA-A Antigens)
RN  - 0 (HLA-B Antigens)
RN  - 0 (HLA-DR Antigens)
RN  - 0 (Histocompatibility Antigens Class I)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Amino Acid Sequence/genetics
MH  - Amino Acid Substitution/genetics/immunology
MH  - Amino Acids/chemistry/genetics
MH  - Child
MH  - Child, Preschool
MH  - Graft Survival/*genetics/*immunology
MH  - HLA-A Antigens/genetics/immunology
MH  - HLA-B Antigens/genetics/immunology
MH  - HLA-DR Antigens/genetics/immunology
MH  - Histocompatibility Antigens Class I/*chemistry/genetics/*immunology
MH  - Histocompatibility Testing
MH  - Humans
MH  - Hydrophobic and Hydrophilic Interactions
MH  - Infant
MH  - Kidney Transplantation/*immunology
MH  - Middle Aged
MH  - Proportional Hazards Models
MH  - Static Electricity
MH  - *Tissue Donors
MH  - United Kingdom
MH  - Young Adult
EDAT- 2010/06/12 06:00
MHDA- 2011/02/01 06:00
CRDT- 2010/06/12 06:00
PHST- 2010/04/08 00:00 [received]
PHST- 2010/05/28 00:00 [revised]
PHST- 2010/06/01 00:00 [accepted]
PHST- 2010/06/12 06:00 [entrez]
PHST- 2010/06/12 06:00 [pubmed]
PHST- 2011/02/01 06:00 [medline]
AID - S0198-8859(10)00136-9 [pii]
AID - 10.1016/j.humimm.2010.06.003 [doi]
PST - ppublish
SO  - Hum Immunol. 2010 Sep;71(9):851-6. doi: 10.1016/j.humimm.2010.06.003. Epub 2010 
      Jun 9.