PMID- 20539268
OWN - NLM
STAT- MEDLINE
DCOM- 20110830
LR  - 20161125
IS  - 1824-4785 (Print)
IS  - 1824-4785 (Linking)
VI  - 55
IP  - 1
DP  - 2011 Feb
TI  - Prognostic role of the PET parameter maximum standardized uptake value in non 
      small cell lung cancer: analysis in tumour of diameter >/= and <25 mm.
PG  - 72-80
AB  - AIM: The aim of this study was to evaluate whether the primary tumour maximum 
      standardized uptake value (SUV(max)) plays an independent prognostic role in 
      patients with non small cell lung cancer (NSCLC) and whether this role is limited 
      by partial volume effect (PVE) and motion artefacts. METHODS: One hundred and 
      fifty-three consecutive patients underwent PET exam, surgery (R0 resection) and 
      follow-up (mean 20.3; range 6-44.8 months). Correlation with Disease Free and 
      Overall Survival (DFS, OS) was evaluated in the entire population for: SUV(max), 
      clinical and histopathological features and pathological stage. To evaluate the 
      PVE and motion artefacts' interferences on SUV calculation, the correlation 
      between SUV(max) and DFS/OS was also calculated in the groups of patients with 
      tumour diameter >/= and < than 25 mm (group A and B, respectively). RESULTS: In the 
      entire population only TNM and SUV(max) resulted correlated with DFS/OS. However, 
      SUV(max) was significantly correlated with DFS/OS in group A but not in group B. 
      Furthermore, only in the group of patients with primary tumour diameter >/= 25 mm 
      (group A), tumour diameter, tumour histotype, and tumour necrosis resulted 
      significantly related with SUV(max) at both uni and multivariate analysis. 
      CONCLUSION: TNM together with SUV(max) could be useful in giving a better 
      prognostic stratification of patients with NSCLC; however technical limitations 
      in the SUV calculation must be taken into account in patients with tumour 
      diameter <25 mm.
FAU - Pelosi, E
AU  - Pelosi E
AD  - PET Centre IRMET S.p.A., Turin, Italy. e.pelosi@irmet.com
FAU - Bille, A
AU  - Bille A
FAU - Skanjeti, A
AU  - Skanjeti A
FAU - Errico, L
AU  - Errico L
FAU - Arena, V
AU  - Arena V
FAU - Ardissone, F
AU  - Ardissone F
FAU - Borasio, P
AU  - Borasio P
FAU - Mancini, M
AU  - Mancini M
LA  - eng
PT  - Journal Article
DEP - 20100611
PL  - Italy
TA  - Q J Nucl Med Mol Imaging
JT  - The quarterly journal of nuclear medicine and molecular imaging : official 
      publication of the Italian Association of Nuclear Medicine (AIMN) [and] the 
      International Association of Radiopharmacology (IAR), [and] Section of the 
      Society of...
JID - 101213861
SB  - IM
MH  - Aged
MH  - Carcinoma, Non-Small-Cell Lung/*diagnostic imaging/*pathology/surgery
MH  - Disease-Free Survival
MH  - Female
MH  - Humans
MH  - Kaplan-Meier Estimate
MH  - Lung Neoplasms/*diagnostic imaging/*pathology/surgery
MH  - Male
MH  - Middle Aged
MH  - Neoplasm Staging
MH  - *Positron-Emission Tomography
MH  - Prognosis
MH  - Retrospective Studies
EDAT- 2010/06/12 06:00
MHDA- 2011/08/31 06:00
CRDT- 2010/06/12 06:00
PHST- 2010/06/12 06:00 [entrez]
PHST- 2010/06/12 06:00 [pubmed]
PHST- 2011/08/31 06:00 [medline]
AID - R39102161 [pii]
PST - ppublish
SO  - Q J Nucl Med Mol Imaging. 2011 Feb;55(1):72-80. Epub 2010 Jun 11.