PMID- 20541363
OWN - NLM
STAT- MEDLINE
DCOM- 20110207
LR  - 20200914
IS  - 1873-1244 (Electronic)
IS  - 0899-9007 (Linking)
VI  - 26
IP  - 10
DP  - 2010 Oct
TI  - Beneficial effects of oligopeptides from marine salmon skin in a rat model of 
      type 2 diabetes.
PG  - 1014-20
LID - 10.1016/j.nut.2010.01.011 [doi]
AB  - OBJECTIVE: This study aimed at investigating whether treatment with oligopeptides 
      from marine salmon skin (OMSS) could modulate type 2 diabetes mellitus 
      (T2DM)-related hyperglycemia and beta-cell apoptosis in rats induced by high fat 
      diet and low doses of streptozotocin and its therapeutic mechanisms. METHODS: 
      Groups of T2DM rats were treated with OMSS or bovine serum albumin (3.0 g/kg/d) 
      for 4 wk and their blood samples, together with those of normal control rats, 
      were collected before and 4 wk after treatment. The levels of fasting blood 
      glucose (FBG) and insulin, serum superoxide dismutase (SOD), malondialdehyde 
      (MDA), and glutathione (GSH), tumor necrosis factor-alpha (TNFalpha), and 
      interferon-gamma (IFNgamma) in rats were determined. The islet cell apoptosis and 
      Fas/FasL expression were detected by TUNEL and immunohistochemistry. RESULTS: In 
      comparison with control rats, higher levels of FBG and frequency of apoptotic 
      islet cells were detected in the bovine serum albumin group of diabetic rats, 
      accompanied by higher levels of Fas expression in the pancreatic islets, serum 
      TNFalpha, IFNgamma, and MDA, but lower levels of SOD and GSH. However, the levels of FBG 
      and frequency of apoptotic islet cells were significantly reduced in OMSS-treated 
      rats. Lower levels of Fas expression were observed in the pancreatic islets of 
      OMSS-treated rats. Significantly reduced levels of serum TNFalpha, IFNgamma, and MDA, but 
      increased levels of SOD and GSH, were detected in OMSS-treated rats. CONCLUSIONS: 
      Treatment with OMSS significantly reduced FBG in diabetic rats. This antidiabetic 
      activity may be mediated by down-regulating T2DM-related oxidative stress and 
      inflammation, protecting the pancreatic beta-cells from apoptosis.
CI  - Copyright (c) 2010 Elsevier Inc. All rights reserved.
FAU - Zhu, Cui-Feng
AU  - Zhu CF
AD  - Department of Nutrition and Food Hygiene, School of Public Health, Peking 
      University, Beijing, PR China.
FAU - Peng, Hong-Bing
AU  - Peng HB
FAU - Liu, Gui-Qin
AU  - Liu GQ
FAU - Zhang, Fan
AU  - Zhang F
FAU - Li, Yong
AU  - Li Y
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100611
PL  - United States
TA  - Nutrition
JT  - Nutrition (Burbank, Los Angeles County, Calif.)
JID - 8802712
RN  - 0 (Anti-Inflammatory Agents)
RN  - 0 (Antioxidants)
RN  - 0 (Blood Glucose)
RN  - 0 (Dietary Fats)
RN  - 0 (Fas protein, rat)
RN  - 0 (Hypoglycemic Agents)
RN  - 0 (Oligopeptides)
RN  - 0 (Protein Hydrolysates)
RN  - 0 (Serum Albumin)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 0 (fas Receptor)
RN  - 4Y8F71G49Q (Malondialdehyde)
RN  - 5W494URQ81 (Streptozocin)
RN  - 82115-62-6 (Interferon-gamma)
RN  - EC 1.15.1.1 (Superoxide Dismutase)
RN  - GAN16C9B8O (Glutathione)
SB  - IM
MH  - Animals
MH  - Anti-Inflammatory Agents/pharmacology/therapeutic use
MH  - Antioxidants/metabolism/pharmacology/therapeutic use
MH  - Apoptosis/drug effects
MH  - Blood Glucose/*metabolism
MH  - Diabetes Mellitus, Experimental/blood/*drug therapy
MH  - Dietary Fats/adverse effects
MH  - Glutathione/blood
MH  - Hyperglycemia/drug therapy
MH  - Hypoglycemic Agents/pharmacology/*therapeutic use
MH  - Interferon-gamma/blood
MH  - Islets of Langerhans/*drug effects/physiology
MH  - Male
MH  - Malondialdehyde/blood
MH  - Oligopeptides/pharmacology/*therapeutic use
MH  - Oxidative Stress/drug effects
MH  - Protein Hydrolysates/pharmacology/*therapeutic use
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - *Salmon
MH  - Serum Albumin
MH  - Streptozocin/administration & dosage
MH  - Superoxide Dismutase/blood
MH  - Tumor Necrosis Factor-alpha/blood
MH  - fas Receptor/metabolism
EDAT- 2010/06/15 06:00
MHDA- 2011/02/08 06:00
CRDT- 2010/06/15 06:00
PHST- 2009/02/25 00:00 [received]
PHST- 2009/09/01 00:00 [revised]
PHST- 2010/01/06 00:00 [accepted]
PHST- 2010/06/15 06:00 [entrez]
PHST- 2010/06/15 06:00 [pubmed]
PHST- 2011/02/08 06:00 [medline]
AID - S0899-9007(10)00037-7 [pii]
AID - 10.1016/j.nut.2010.01.011 [doi]
PST - ppublish
SO  - Nutrition. 2010 Oct;26(10):1014-20. doi: 10.1016/j.nut.2010.01.011. Epub 2010 Jun 
      11.