PMID- 20542805
OWN - NLM
STAT- MEDLINE
DCOM- 20100928
LR  - 20101118
IS  - 1969-6213 (Electronic)
IS  - 1774-024X (Linking)
VI  - 6
IP  - 1
DP  - 2010 May
TI  - Incidence, predictors and prognostic importance of bleeding after primary PCI for 
      ST-elevation myocardial infarction.
PG  - 106-11
LID - EIJV6I1A16 [pii]
AB  - AIMS: To investigate incidence, predictors and prognosis of bleeding in ST 
      elevation myocardial infarction (STEMI) patients who underwent primary 
      percutaneous coronary intervention (PCI). METHODS AND RESULTS: A large scale, 
      prospective, observational study was performed between 1991 and 2004 in a single 
      teaching hospital in The Netherlands including all consecutive STEMI patients who 
      underwent primary PCI. The independent association between both major and minor 
      bleeding and one year mortality was evaluated using Cox proportional hazard 
      models. A total of 5,030 patients were included, of whom 109 patients (2%) had 
      cardiac surgery within 48 hours. Data on bleeding <48 hours were available in 
      4,717 patients (96%). Of these, 80 (1.6%) had major bleeding, whereas minor 
      bleeding was observed in 266 patients (5.6%). Independent predictors of minor 
      bleeding were advanced age, multivessel disease, Killip class > or = 2 on 
      admission, anterior MI location and TIMI 0 flow before PCI. Killip class > or = 2 
      on admission was an independent predictor of major bleeding. Major bleeding (HR 
      3.5 [95% CI 2.3-5.4]) was associated with an increased risk of death at one year. 
      CONCLUSIONS: After primary PCI, the incidence of major bleeding is less than 2%. 
      Although relatively infrequent, major bleeding complications are strongly and 
      independently related to short- and midterm mortality.
FAU - Hermanides, Renicus S
AU  - Hermanides RS
AD  - Isala klinieken, Location Weezenlanden, Department of Cardiology, Zwolle, The 
      Netherlands.
FAU - Ottervanger, Jan-Paul
AU  - Ottervanger JP
FAU - Dambrink, Jan-Henk E
AU  - Dambrink JH
FAU - de Boer, Menko-Jan
AU  - de Boer MJ
FAU - Hoorntje, Jan C A
AU  - Hoorntje JC
FAU - Gosselink, A T Marcel
AU  - Gosselink AT
FAU - Suryapranata, Harry
AU  - Suryapranata H
FAU - van 't Hof, Arnoud W J
AU  - van 't Hof AW
LA  - eng
PT  - Journal Article
PL  - France
TA  - EuroIntervention
JT  - EuroIntervention : journal of EuroPCR in collaboration with the Working Group on 
      Interventional Cardiology of the European Society of Cardiology
JID - 101251040
RN  - 0 (Anticoagulants)
RN  - 0 (Platelet Aggregation Inhibitors)
SB  - IM
MH  - Adult
MH  - Age Factors
MH  - Aged
MH  - Aged, 80 and over
MH  - Angioplasty, Balloon, Coronary/*adverse effects/mortality
MH  - Anticoagulants/adverse effects
MH  - Chi-Square Distribution
MH  - Female
MH  - Hemorrhage/*etiology/mortality
MH  - Hospitals, Teaching
MH  - Humans
MH  - Incidence
MH  - Kaplan-Meier Estimate
MH  - Logistic Models
MH  - Male
MH  - Middle Aged
MH  - Myocardial Infarction/*therapy
MH  - Netherlands
MH  - Platelet Aggregation Inhibitors/adverse effects
MH  - Proportional Hazards Models
MH  - Prospective Studies
MH  - Registries
MH  - Risk Assessment
MH  - Risk Factors
MH  - Severity of Illness Index
MH  - Time Factors
MH  - Treatment Outcome
MH  - Young Adult
EDAT- 2010/06/15 06:00
MHDA- 2010/09/30 06:00
CRDT- 2010/06/15 06:00
PHST- 2010/06/15 06:00 [entrez]
PHST- 2010/06/15 06:00 [pubmed]
PHST- 2010/09/30 06:00 [medline]
AID - EIJV6I1A16 [pii]
PST - ppublish
SO  - EuroIntervention. 2010 May;6(1):106-11.