PMID- 20543199
OWN - NLM
STAT- MEDLINE
DCOM- 20101116
LR  - 20101206
IS  - 1532-2092 (Electronic)
IS  - 1099-5129 (Linking)
VI  - 12
IP  - 8
DP  - 2010 Aug
TI  - Survival in New York Heart Association class IV heart failure patients treated 
      with cardiac resynchronization therapy compared with patients on optimal 
      pharmacological treatment.
PG  - 1136-40
LID - 10.1093/europace/euq163 [doi]
AB  - AIMS: Although the benefit of cardiac resynchronization therapy (CRT) in selected 
      patients with heart failure is well established, its effect on mortality in New 
      York Heart Association (NYHA) class IV patients remains unclear. Our study 
      evaluated the effect of CRT on urgent transplant-free survival in NYHA class IV 
      patients treated with CRT, compared with medication-only treatment. METHODS AND 
      RESULTS: Forty NYHA class IV patients treated with CRT (80% men, 62.5% ischaemic, 
      mean age of 65) were matched 1:1 by age, gender and aetiology of cardiomyopathy 
      with patients treated with optimal medical therapy (OPT group). No significant 
      differences were found between the groups in left ventricular diastolic diameter 
      (71 +/- 6 vs. 73 +/- 9 mm), left ventricular systolic diameter (58 +/- 7 vs. 61 
      +/- 11 mm), and left ventricular ejection fraction (23 +/- 5 vs. 22 +/- 6%). Mean 
      follow-up was 13.2 +/- 9.5 months for the CRT group and 17.3 +/- 11.6 months for 
      the OPT group. Time to all-cause death or urgent transplantation [hazard ratios 
      (HR), 1.29; 95% CI: 0.59-2.83; P = 0.52] or to cardiovascular death or urgent 
      transplantation (HR, 1.53; 95% CI: 0.64-3.67; P = 0.34) was not reduced 
      significantly in patients treated with CRT. CONCLUSION: In this study, CRT did 
      not significantly improve survival of NYHA class IV heart failure patients 
      compared with pharmacological therapy.
FAU - Castel, Maria Angeles
AU  - Castel MA
AD  - Thorax Clinic Institute, Hospital Clinic, Institut d'Investigacions Biomediques 
      August Pi i Sunyer, University of Barcelona, Villarroel 170, Barcelona 08036, 
      Spain. macastel@clilnic.ub.es
FAU - Magnani, Santiago
AU  - Magnani S
FAU - Mont, Lluis
AU  - Mont L
FAU - Roig, Eulalia
AU  - Roig E
FAU - Tamborero, David
AU  - Tamborero D
FAU - Mendez-Zurita, Francisco
AU  - Mendez-Zurita F
FAU - Femenia, Jose Francisco
AU  - Femenia JF
FAU - Tolosana, Jose Maria
AU  - Tolosana JM
FAU - Perez-Villa, Felix
AU  - Perez-Villa F
FAU - Brugada, Josep
AU  - Brugada J
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100612
PL  - England
TA  - Europace
JT  - Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal 
      of the working groups on cardiac pacing, arrhythmias, and cardiac cellular 
      electrophysiology of the European Society of Cardiology
JID - 100883649
RN  - 0 (Adrenergic beta-Antagonists)
RN  - 0 (Angiotensin II Type 1 Receptor Blockers)
RN  - 0 (Angiotensin-Converting Enzyme Inhibitors)
RN  - 0 (Diuretics)
SB  - IM
CIN - Europace. 2010 Dec;12(12):1797; author reply 1797-8. PMID: 20876275
MH  - Adrenergic beta-Antagonists/therapeutic use
MH  - Aged
MH  - Angiotensin II Type 1 Receptor Blockers/therapeutic use
MH  - Angiotensin-Converting Enzyme Inhibitors/*therapeutic use
MH  - Cardiac Pacing, Artificial/*mortality/*statistics & numerical data
MH  - Death, Sudden, Cardiac/epidemiology
MH  - Defibrillators, Implantable/statistics & numerical data
MH  - Diuretics/therapeutic use
MH  - Female
MH  - Follow-Up Studies
MH  - Heart Failure/*drug therapy/*mortality
MH  - Heart Transplantation/mortality
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - New York/epidemiology
MH  - Severity of Illness Index
MH  - Societies, Medical
EDAT- 2010/06/15 06:00
MHDA- 2010/11/17 06:00
CRDT- 2010/06/15 06:00
PHST- 2010/06/15 06:00 [entrez]
PHST- 2010/06/15 06:00 [pubmed]
PHST- 2010/11/17 06:00 [medline]
AID - euq163 [pii]
AID - 10.1093/europace/euq163 [doi]
PST - ppublish
SO  - Europace. 2010 Aug;12(8):1136-40. doi: 10.1093/europace/euq163. Epub 2010 Jun 12.