PMID- 20545902
OWN - NLM
STAT- MEDLINE
DCOM- 20110224
LR  - 20111117
IS  - 1399-0039 (Electronic)
IS  - 0001-2815 (Linking)
VI  - 76
IP  - 5
DP  - 2010 Nov
TI  - Regional differences in HLA antigen and haplotype frequency distributions in 
      Germany and their relevance to the optimization of hematopoietic stem cell donor 
      recruitment.
PG  - 362-79
LID - 10.1111/j.1399-0039.2010.01520.x [doi]
AB  - We analyzed regional differences in human leukocyte antigen (HLA)-A, -B, and -DR 
      antigen and haplotype frequencies based on a sample of approximately 320,000 
      German donors in order to identify regions that are especially suited for ongoing 
      stem cell donor recruitment. Geographic partitioning was carried out by postal 
      code regions. Analysis of genetic distances suggests the existence of three 
      regional clusters in South (regions 6-9), East (0-1), and Northwest (2-5) 
      Germany. The southern cluster shows most favorable characteristics with respect 
      to haplotypic and phenotypic diversity and the occurrence of rare HLA antigens. 
      The opposite behavior is shown by regions 2-4 of the northwestern cluster. As a 
      result of lower HLA diversity, completeness of a regional donor file in region 4 
      with 100,000 donors would be higher than that of a file in region 7 with 170,000 
      donors. This fact shows the relevance of regional HLA differences for practical 
      donor registry planning. Results such as those presented in this work can be used 
      to diminish the problem of decreasing marginal benefit of donor recruitment, as 
      more than 13 million donors are registered worldwide today.
CI  - (c) 2010 John Wiley & Sons A/S.
FAU - Schmidt, A H
AU  - Schmidt AH
AD  - DKMS German Bone Marrow Donor Center, Tubingen, Germany. schmidt@dkms.de
FAU - Solloch, U V
AU  - Solloch UV
FAU - Baier, D
AU  - Baier D
FAU - Stahr, A
AU  - Stahr A
FAU - Wassmuth, R
AU  - Wassmuth R
FAU - Ehninger, G
AU  - Ehninger G
FAU - Rutt, C
AU  - Rutt C
LA  - eng
PT  - Journal Article
DEP - 20100819
PL  - England
TA  - Tissue Antigens
JT  - Tissue antigens
JID - 0331072
RN  - 0 (HLA Antigens)
RN  - 0 (HLA-A Antigens)
RN  - 0 (HLA-B Antigens)
RN  - 0 (HLA-DR Antigens)
RN  - 0 (HLA-DRB1 Chains)
SB  - IM
MH  - Alleles
MH  - Female
MH  - Gene Frequency
MH  - Genes, MHC Class I
MH  - Genes, MHC Class II
MH  - Germany
MH  - HLA Antigens/*genetics
MH  - HLA-A Antigens/genetics
MH  - HLA-B Antigens/genetics
MH  - HLA-DR Antigens/genetics
MH  - HLA-DRB1 Chains
MH  - Haplotypes
MH  - *Hematopoietic Stem Cell Transplantation
MH  - Heterozygote
MH  - Humans
MH  - Male
MH  - Registries/statistics & numerical data
MH  - *Tissue Donors
MH  - *Tissue and Organ Procurement
EDAT- 2010/06/16 06:00
MHDA- 2011/02/25 06:00
CRDT- 2010/06/16 06:00
PHST- 2010/06/16 06:00 [entrez]
PHST- 2010/06/16 06:00 [pubmed]
PHST- 2011/02/25 06:00 [medline]
AID - TAN1520 [pii]
AID - 10.1111/j.1399-0039.2010.01520.x [doi]
PST - ppublish
SO  - Tissue Antigens. 2010 Nov;76(5):362-79. doi: 10.1111/j.1399-0039.2010.01520.x. 
      Epub 2010 Aug 19.