PMID- 20546900
OWN - NLM
STAT- MEDLINE
DCOM- 20100712
LR  - 20121115
IS  - 1872-9142 (Electronic)
IS  - 0161-5890 (Linking)
VI  - 47
IP  - 11-12
DP  - 2010 Jul
TI  - DC-STAMP interacts with ER-resident transcription factor LUMAN which becomes 
      activated during DC maturation.
PG  - 1963-73
LID - 10.1016/j.molimm.2010.04.019 [doi]
AB  - Dendritic cells (DCs) are the professional antigen-presenting cells (APC) which 
      efficiently prime the immune response or induce tolerance. We recently identified 
      Dendritic Cell Specific TrAnsMembrane Protein (DC-STAMP), a novel 470 amino acid 
      protein preferentially expressed by dendritic cells. Previously we demonstrated 
      that DC-STAMP re-localizes towards the Golgi upon DC maturation. To identify 
      proteins that interact with DC-STAMP, a yeast-2-hybrid analysis was performed. 
      Here, we report a physically interacting partner of DC-STAMP in the endoplasmic 
      reticulum (ER), called LUMAN (also known as CREB3 or LZIP). LUMAN was previously 
      described as an ER-resident transcription factor with unknown function. It is 
      activated in a process called regulated intramembrane proteolysis (RIP), which 
      involves translocation to the Golgi and subsequent proteolytic cleavage. The 
      proteolytically activated form of the protein then translocates to the nucleus. 
      Our data indicate that DC-STAMP plays an important role in the modulation of 
      LUMAN activation. Moreover, we demonstrate that LUMAN is endogenously expressed 
      by DC and becomes activated by RIP upon DC maturation induced by various 
      different stimuli. These data define LUMAN/DC-STAMP as a novel regulatory circuit 
      in DC.
CI  - (c) 2010 Elsevier Ltd. All rights reserved.
FAU - Eleveld-Trancikova, Dagmar
AU  - Eleveld-Trancikova D
AD  - Department of Tumor Immunology, Nijmegen Centre for Molecular Life Sciences, 
      Radboud University Nijmegen Medical Centre, PO Box 9101, 6500 HB Nijmegen, The 
      Netherlands.
FAU - Sanecka, Anna
AU  - Sanecka A
FAU - van Hout-Kuijer, Maaike A
AU  - van Hout-Kuijer MA
FAU - Looman, Maaike W G
AU  - Looman MW
FAU - Hendriks, Ilona A M
AU  - Hendriks IA
FAU - Jansen, Bastiaan J H
AU  - Jansen BJ
FAU - Adema, Gosse J
AU  - Adema GJ
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100523
PL  - England
TA  - Mol Immunol
JT  - Molecular immunology
JID - 7905289
RN  - 0 (Adaptor Proteins, Signal Transducing)
RN  - 0 (CREB3 protein, human)
RN  - 0 (Cyclic AMP Response Element-Binding Protein)
RN  - 0 (DCSTAMP protein, human)
RN  - 0 (Membrane Proteins)
RN  - 0 (RNA, Messenger)
SB  - IM
MH  - Active Transport, Cell Nucleus
MH  - Adaptor Proteins, Signal Transducing
MH  - Animals
MH  - Binding Sites
MH  - CHO Cells
MH  - Cell Line
MH  - Cricetinae
MH  - Cricetulus
MH  - Cyclic AMP Response Element-Binding Protein/genetics/*physiology
MH  - Dendritic Cells/*physiology
MH  - Humans
MH  - Membrane Proteins/genetics/*physiology
MH  - Protein Transport
MH  - RNA, Messenger/analysis
EDAT- 2010/06/16 06:00
MHDA- 2010/07/14 06:00
CRDT- 2010/06/16 06:00
PHST- 2010/04/13 00:00 [received]
PHST- 2010/04/29 00:00 [accepted]
PHST- 2010/06/16 06:00 [entrez]
PHST- 2010/06/16 06:00 [pubmed]
PHST- 2010/07/14 06:00 [medline]
AID - S0161-5890(10)00158-6 [pii]
AID - 10.1016/j.molimm.2010.04.019 [doi]
PST - ppublish
SO  - Mol Immunol. 2010 Jul;47(11-12):1963-73. doi: 10.1016/j.molimm.2010.04.019. Epub 
      2010 May 23.