PMID- 20547010
OWN - NLM
STAT- MEDLINE
DCOM- 20101210
LR  - 20231213
IS  - 1618-0631 (Electronic)
IS  - 0344-0338 (Linking)
VI  - 206
IP  - 9
DP  - 2010 Sep 15
TI  - Distinct compartmental distribution of mature and immature dendritic cells in 
      esophageal squamous cell carcinoma.
PG  - 602-6
LID - 10.1016/j.prp.2010.03.011 [doi]
AB  - Dendritic cells (DCs) play a critical role in generating anti-tumor immunity. DC 
      functional defect has been related to the growth and progression of various human 
      cancers. In esophageal squamous cell carcinoma (ESCC), the examination of DCs 
      using immunohistochemistry (IHC) with anti-S100 antibody has demonstrated an 
      increased infiltration of DCs into the tumor mass, however, the distribution 
      patterns of DCs at different maturation states in ESCC are not fully evaluated. 
      In this study, we immunohistochemically analyzed the DC maturation status by 
      examining the S100-positive DCs, CD1alpha-positive immature DCs (iDCs), and 
      CD208-positive mature DCs (mDCs) and their distribution patterns in 45 ESCCs and 
      10 control tissues. The IHC analysis showed that the number of S100-positive DCs 
      was increased in both the cancer epithelium and tumor stroma. Further phenotypic 
      analyses revealed that intraepithelial DCs in the cancer mass were predominantly 
      CD1alpha-positive iDCs. Whereas DCs presented in the tumor stroma were 
      exclusively CD208-positive mDCs, CD208-positive mDCs were particularly dense in 
      the margin of cancerous lesions and formed clusters with CD3-positive 
      lymphocytes. The number of CD208-positive mDCs in the tumor mass was 
      significantly lower than the number of CD1alpha-positive iDCs. The current 
      results suggest that ESCC tissue comprises a high frequency of iDCs in the 
      cancerous epithelium and a low density of mDCs in the tumor stroma. Such a 
      distinct distribution pattern may reflect the ongoing DC tracking in ESCCs.
CI  - Copyright 2010 Elsevier GmbH. All rights reserved.
FAU - Liu, Jinzhong
AU  - Liu J
AD  - Department of Pathology, the Fourth Affiliated Hospital of Zhengzhou University, 
      Zhengzhou, Henan, China.
FAU - Lu, Gaofeng
AU  - Lu G
FAU - Li, Zhenfeng
AU  - Li Z
FAU - Tang, Fuai
AU  - Tang F
FAU - Liu, Yiqing
AU  - Liu Y
FAU - Cui, Guanglin
AU  - Cui G
LA  - eng
PT  - Journal Article
DEP - 20100523
PL  - Germany
TA  - Pathol Res Pract
JT  - Pathology, research and practice
JID - 7806109
RN  - 0 (CD3 Complex)
RN  - 0 (LAMP3 protein, human)
RN  - 0 (Lysosomal Membrane Proteins)
RN  - 0 (Neoplasm Proteins)
SB  - IM
MH  - CD3 Complex/biosynthesis
MH  - Carcinoma, Squamous Cell/*immunology/pathology
MH  - Cell Differentiation
MH  - Dendritic Cells/*cytology
MH  - Esophageal Neoplasms/*immunology/pathology
MH  - Female
MH  - Humans
MH  - Immunohistochemistry
MH  - Lysosomal Membrane Proteins/biosynthesis
MH  - Male
MH  - Neoplasm Proteins/biosynthesis
EDAT- 2010/06/16 06:00
MHDA- 2010/12/14 06:00
CRDT- 2010/06/16 06:00
PHST- 2010/01/12 00:00 [received]
PHST- 2010/03/16 00:00 [revised]
PHST- 2010/03/19 00:00 [accepted]
PHST- 2010/06/16 06:00 [entrez]
PHST- 2010/06/16 06:00 [pubmed]
PHST- 2010/12/14 06:00 [medline]
AID - S0344-0338(10)00106-8 [pii]
AID - 10.1016/j.prp.2010.03.011 [doi]
PST - ppublish
SO  - Pathol Res Pract. 2010 Sep 15;206(9):602-6. doi: 10.1016/j.prp.2010.03.011. Epub 
      2010 May 23.